Results 121 to 130 of about 12,839 (218)

Role of thymic stromal lymphopoietin (TSLP) in asthma

, 2021
Thymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line and characterized as a lymphocyte growth factor. TSLP is predominantly expressed by lung and gut epithelial cells, keratinocytes, and by dendritic cells (DCs). TSLP can be produced also by airway smooth muscle (ASM) cells, mast cells,
openaire   +1 more source

A dual computational and experimental strategy to enhance TSLP antibody affinity for improved asthma treatment.

PLoS Computational Biology
Thymic stromal lymphopoietin is a key cytokine involved in the pathogenesis of asthma and other allergic diseases. Targeting TSLP and its signaling pathways is increasingly recognized as an effective strategy for asthma treatment.
Yitong Lv, He Gong, Xuechao Liu, Jia Hao, Lei Xu, Zhiwei Sun, Changyuan Yu, Lida Xu   +7 more
doaj   +1 more source

Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis [PDF]

, 2015
OBJECTIVE: GCA is a large- and medium-vessel arteritis characterized by a range of histological patterns of vascular wall injury. The aim of this study was to immunologically characterize the various histological patterns of GCA.
ALESSANDRO, Riccardo, Boiardi, L., CANNIZZARO, Alessandra, Cavazza, A., CICCIA, Francesco, GUGGINO, Giuliana, IACOPINO, Domenico, Maugeri, R., Rizzo, A., Salvarani, C., TRIOLO, Giovanni   +10 more
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Inflammatory Cytokine TSLP Stimulates Platelet Secretion and Potentiates Platelet Aggregation via a TSLPR-Dependent PI3K/Akt Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: Thymic stromal lymphopoietin (TSLP) plays an important role in inflammatory diseases and is over-expressed in human atherosclerotic artery specimens.
Jangchuan Dong, Jing Lin, Boyuan Wang, Shaolin He, Chun Wu, Kishan Kumar Kushwaha, Nilesh Mohabeer, Yousu Su, Hongcheng Fang, Kai Huang, Dazhu Li   +10 more
doaj   +1 more source

A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype

Allergology International, 2013
Atopy is a phenotypically heterogeneous condition, and the extent to which atopy accounts for asthma is controversial. In this study, we aimed to identify the presence of distinct sensitization patterns to common inhaled allergens and their association with asthma, allergic rhinitis and TSLP genotypes.We studied 1683 adults from Tsukuba, a city in ...
Hiroaki Iijima, Yoshiko Kaneko, Hideyasu Yamada, Yohei Yatagai, Hironori Masuko, Tohru Sakamoto, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Satoshi Konno, Masaharu Nishimura, Emiko Noguchi, Nobuyuki Hizawa   +12 more
openaire   +3 more sources

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies

Allergology International, 2017
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression.
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono   +6 more
doaj   +1 more source

TSLP: contrasting roles in cancer

Frontiers in Immunology
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto, Remo Poto, Remo Poto, Gianni Marone, Gianni Marone, Gianni Marone, Steven F. Ziegler, Steven F. Ziegler, Steven F. Ziegler, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +11 more
doaj   +1 more source

木村病においてはTSLP, TSLP受容体の発現が亢進している [PDF]

, 2015
博士（医学） 乙第2870号（主論文の要旨、要約、審査結果の要旨）博士（医学 ...
崎谷 恵理
core   +1 more source

Effects of Quercetin Treatment on Epithelium-derived Cytokines and Epithelial Cell Apoptosis in Allergic Airway Inflammation Mice Model

Iranian Journal of Allergy, Asthma and Immunology, 2017
Quercetin is a dietary flavonoid which has anti-inflammatory effects. This study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model.
Sule Caglayan Sozmen, Meral Karaman, Serap Cilaker Micili, Sakine Isik, Alper Bagriyanik, Zeynep Arikan Ayyildiz, Nevin Uzuner, Ozden Anal, Ozkan Karaman   +8 more
doaj  

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core