Results 121 to 130 of about 199,261 (304)
20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-β
20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, has been shown to modulate the growth of vascular smooth muscle cells (VSMCs).
Chan-Jung Liang+3 more
doaj
Effect of age, sex, and hormonal state on tritiated thymidine uptake by rat pituitary. [PDF]
W. A. J. Crane, R S Loomes
openalex +1 more source
Highlights From the 2nd Turin International Workshop on Liver Machine Perfusion
ABSTRACT The 2nd Turin International Workshop on Liver Machine Perfusion took place in Turin, Italy, on November 22, 2024. Leading experts came together to discuss the current applications, limitations, and future directions of this technology, with a primary focus on but not limited to liver transplantation.
Damiano Patrono+5 more
wiley +1 more source
Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu+6 more
wiley +1 more source
Dengue fever has become a global health issue, the development of dengue vaccine has not yet been established. Medicinal plants are an ideal alternative for DENV infection drugs.
Moh Mirza Nuryady+2 more
doaj +1 more source
PROLIFERATIVE ACTIVITY OF THE LYMPHATIC TISSUES OF RATS AS STUDIED WITH TRITIUM-LABELED THYMIDINE [PDF]
Charles G. Craddock+3 more
openalex +1 more source
HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman+4 more
wiley +1 more source
Schistosomiasis mansoni: evidence for a milder response in germfree mice
Germfree (GF and conventional (CV) mice were infected intraperitoneally with GF cercariae of Schistosoma mansoni and kept for six weeks. Twenty four hours before killing, they were injected with [³H]-thymidine.
Leda Q. Viera, Tasso Moraes-santos
doaj
Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley +1 more source
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang+16 more
wiley +1 more source