Results 181 to 190 of about 107,915 (237)

The role of serum thymidine kinase 1 activity in neoadjuvant-treated HER2-positive breast cancer: biomarker analysis from the Swedish phase II randomized PREDIX HER2 trial. [PDF]

open access: yesBreast Cancer Res Treat
Zhu Y   +18 more
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The thymidine phosphorylating kinases

Biochimica et Biophysica Acta, 1961
Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI   +3 more
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Mitochondrial-specific thymidine kinase

Archives of Biochemistry and Biophysics, 1973
Abstract Thymidine kinase activity has been demonstrated in purified mitochondria prepared from animal tissue, wild-type tissue culture cells, and BrdU-resistant cell lines. The BrdU-resistant cell lines lack a soluble cytoplasmic thymidine kinase present in wild-type cells, but continue to exhibit the minor mitochondrial activity.
A J, Berk, B J, Meyer, D A, Clayton
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Mitochondrial Thymidine Kinase Inhibitors

Current Topics in Medicinal Chemistry, 2005
Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.
María-Jesús, Pérez-Pérez   +6 more
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Thymidine Kinases in Archaea

Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen   +3 more
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Methotrexate decreases thymidine kinase activity

Biochemical and Biophysical Research Communications, 1992
MTX cytotoxicity is not fully explained by its well-known inhibition of dihydrofolate reductase activity which leads to a decrease in the dTMP synthase reaction, since TdR kinase which converts TdR to dTMP could readily circumvent MTX action through this salvage activity.
M, Abonyi   +4 more
openaire   +2 more sources

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