Results 201 to 210 of about 67,342 (249)
Some of the next articles are maybe not open access.
Thymidine kinase: diagnostic and prognostic potential
Expert Review of Molecular Diagnostics, 2001Thymidine kinase is a cell cycle-dependent marker that can be detected in the serum of patients diagnosed with many different types of cancer. Serum levels of thymidine kinase have also been shown to reflect the progression of cancer as well as an indication of the efficacy of chemotherapeutic intervention. A new monoclonal antibody assay for thymidine
Kim L O'Neill, Byron K Murray
exaly +3 more sources
The role of thymidine kinase in cancer diseases
Expert Opinion on Medical Diagnostics, 2008Thymidine kinase 1 (TK 1-fetal) is a cell cycle-dependent marker that increases dramatically during the S-phase of the cell cycle. In this review, the authors discuss serum levels of thymidine kinase in a variety of neoplasias. Determination of thymidine kinase helps to monitor the follow-up of solid tumours and haematological malignancies as well as ...
Ondřej Topolcan, Luboš Holubec
exaly +3 more sources
The thymidine phosphorylating kinases
Biochimica et Biophysica Acta, 1961Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI +3 more
openaire +2 more sources
Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
openaire +2 more sources
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
openaire +2 more sources
Mitochondrial-specific thymidine kinase
Archives of Biochemistry and Biophysics, 1973Abstract Thymidine kinase activity has been demonstrated in purified mitochondria prepared from animal tissue, wild-type tissue culture cells, and BrdU-resistant cell lines. The BrdU-resistant cell lines lack a soluble cytoplasmic thymidine kinase present in wild-type cells, but continue to exhibit the minor mitochondrial activity.
A J, Berk, B J, Meyer, D A, Clayton
openaire +2 more sources
Feedback inhibition of thymidine kinase by thymidine triphosphate
Experimental Cell Research, 1963THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
openaire +2 more sources
Thymidine kinase and cancer monitoring
Cancer Letters, 2012Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated.
Stefan, Aufderklamm +6 more
openaire +2 more sources
Thymidine Kinase in Megaloblastic Anaemia
British Journal of Haematology, 1976Summary. Thymidine kinase has been measured in phytohaemagglutinin (PHA)‐stimulated lymphocytes from 13 normal subjects and eight patients with megaloblastic anaemia. The levels in normal subjects ranged from 0.20 to 2.10 units/mg protein (mean 0.903 units/mg protein) and in megaloblastic anaemia from 2.99 to 9.97 units/mg protein (mean 5.76 units/mg ...
J W, Hooton, A V, Hoffbrand
openaire +2 more sources
Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases
Virology, 1987The thymidine kinase (TK) gene of fowlpox virus (FPV) is located in a 2.2-kb HindIII-ClaI fragment derived from a 5.5-kb EcoR1 fragment of the FPV genome. The TK gene was mapped to the region of a 700-bp XbaI fragment contained within this HindIII-ClaI fragment.
D B, Boyle +4 more
openaire +2 more sources
Viral thymidine kinases and their relatives
Pharmacology & Therapeutics, 1992Thymidine kinases were described for cellular life long before it was shown that they could also be encoded by viruses, but the viral thymidine kinase genes were the first to be sequenced. These enzymes have been extraordinarily useful to the researcher, serving first to help label DNA, then to get thymidine analogs incorporated into DNA for ...
openaire +2 more sources