Results 191 to 200 of about 107,915 (237)

Thymidine Kinase in Megaloblastic Anaemia

British Journal of Haematology, 1976
Summary. Thymidine kinase has been measured in phytohaemagglutinin (PHA)‐stimulated lymphocytes from 13 normal subjects and eight patients with megaloblastic anaemia. The levels in normal subjects ranged from 0.20 to 2.10 units/mg protein (mean 0.903 units/mg protein) and in megaloblastic anaemia from 2.99 to 9.97 units/mg protein (mean 5.76 units/mg ...
J W, Hooton, A V, Hoffbrand
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Thymidine kinase and cancer monitoring

Cancer Letters, 2012
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated.
Stefan, Aufderklamm, Tilman, Todenhöfer, Georgios, Gakis, Stephan, Kruck, Joerg, Hennenlotter, Arnulf, Stenzl, Christian, Schwentner   +6 more
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Feedback inhibition of thymidine kinase by thymidine triphosphate

Experimental Cell Research, 1963
THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
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Thymidine Kinase Diversity in Bacteria

Nucleosides, Nucleotides and Nucleic Acids, 2006
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related
M P B, Sandrini, A R, Clausen, B, Munch-Petersen, J, Piskur   +3 more
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Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases

Virology, 1987
The thymidine kinase (TK) gene of fowlpox virus (FPV) is located in a 2.2-kb HindIII-ClaI fragment derived from a 5.5-kb EcoR1 fragment of the FPV genome. The TK gene was mapped to the region of a 700-bp XbaI fragment contained within this HindIII-ClaI fragment.
D B, Boyle, B E, Coupar, A J, Gibbs, L J, Seigman, G W, Both   +4 more
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Thymidine Kinase Expression

1998
The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to discriminate between normal growing cells and virally ...
Markus Hengstschläger, Michael Pfeilstöcker, Edgar Wawra   +2 more
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Thymidine kinase assay in canine lymphoma

Veterinary and Comparative Oncology, 2011
The aim of the study was to evaluate if thymidine kinase (TK) correlated with duration of first remission (DFR) or survival in dogs with lymphoma and if initial TK levels correlated with stage and substage; and also to assess if TK level at diagnosis correlated with immunophenotype.
J W, Elliott, P, Cripps, L, Blackwood
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Thymidine kinase: diagnostic and prognostic potential

Expert Review of Molecular Diagnostics, 2001
Thymidine kinase is a cell cycle-dependent marker that can be detected in the serum of patients diagnosed with many different types of cancer. Serum levels of thymidine kinase have also been shown to reflect the progression of cancer as well as an indication of the efficacy of chemotherapeutic intervention. A new monoclonal antibody assay for thymidine
K L, O'Neill, M R, Buckwalter, B K, Murray   +2 more
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Expression and Substrate Specificities of Human Thymidine Kinase 1, Thymidine Kinase 2 and Deoxycytidine Kinase

1991
Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
S, Eriksson, B, Munch-Petersen, B, Kierdaszuk, E, Arnér   +3 more
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Serum thymidine kinase in colorectal neoplasia

European Journal of Surgical Oncology (EJSO), 1995
Thymidine kinase (TK), an enzyme known to be associated with DNA synthesis, has been measured in the serum of patients with asymptomatic colorectal adenomas (n = 40), asymptomatic colorectal carcinoma (n = 21) and patients known to have hepatic metastases form colorectal tumours (n = 33); enzyme levels have been compared with an age-matched group of ...
W M, Thomas, J F, Robertson, P G, McKenna, K L, O'Neill, M H, Robinson, J D, Hardcastle   +5 more
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