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Viral thymidine kinases and their relatives
Pharmacology & Therapeutics, 1992Thymidine kinases were described for cellular life long before it was shown that they could also be encoded by viruses, but the viral thymidine kinase genes were the first to be sequenced. These enzymes have been extraordinarily useful to the researcher, serving first to help label DNA, then to get thymidine analogs incorporated into DNA for ...
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1991
Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
S, Eriksson +3 more
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Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
S, Eriksson +3 more
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The association of thymidine kinase activity and thymidine transport in Escherichia coli
Gene, 1991We have constructed a series of mutants within the putative nucleoside-binding site of the herpes simplex type-1 virus (HSV-1) thymidine kinase (TK)-encoding gene (tk), contained within an expression vector. While most mutations within this sequence produce an inactive protein, we find no absolute requirement for the wild-type Ile166 and Ala167.
D K, Dube, M S, Horwitz, L A, Loeb
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Gene, 1991
The thymidine kinase (TK)-encoding gene (tdk) of Escherichia coli is located at min 27 of the E. coli genetic map. Sequence analysis of this region revealed an open reading frame of 205 codons. Identification of this region as the E. coli tdk gene was confirmed by its similarity to other TK-encoding genes. The E.
E O, Bockamp, R, Blasco, E, Viñuela
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The thymidine kinase (TK)-encoding gene (tdk) of Escherichia coli is located at min 27 of the E. coli genetic map. Sequence analysis of this region revealed an open reading frame of 205 codons. Identification of this region as the E. coli tdk gene was confirmed by its similarity to other TK-encoding genes. The E.
E O, Bockamp, R, Blasco, E, Viñuela
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Modification of Effects of Radiation on Thymidine Kinase
International Journal of Radiation Biology, 1990Thymidine kinase (TdR-K) and the incorporation of iododeoxyuridine (IUdR) into DNA of murine bone marrow cells are acutely and temporarily inhibited by low doses (0.01 Gy) of whole-body gamma-radiation with a maximal effect at 4 h after exposure and full recovery at 10 h.
K, Hohn-Elkarim +3 more
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Thymidine kinase assay in canine lymphoma
Veterinary and Comparative Oncology, 2011The aim of the study was to evaluate if thymidine kinase (TK) correlated with duration of first remission (DFR) or survival in dogs with lymphoma and if initial TK levels correlated with stage and substage; and also to assess if TK level at diagnosis correlated with immunophenotype.
J W, Elliott, P, Cripps, L, Blackwood
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1998
The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to discriminate between normal growing cells and virally ...
Markus Hengstschläger +2 more
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The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to discriminate between normal growing cells and virally ...
Markus Hengstschläger +2 more
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Induction of thymidine kinase by aflatoxin
Life Sciences, 1966V A, Childs, M S, Legator
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