Therapeutic targeting at genome mutations of liver cancer by the insertion of HSV1 thymidine kinase through Cas9-mediated editing. [PDF]
Kader M +8 more
europepmc +1 more source
Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors. [PDF]
Kim Y +11 more
europepmc +1 more source
Combination of prostate cancer antigen 3 (PCA3), sarcosine, glypican-1 (GPC1), urokinase plasminogen activator receptor (uPAR), and thymidine kinase 1 (TK1), and T2WI and DWI radiomics model for distinguishing benign prostatic hyperplasia, prostate cancer, and prostatitis. [PDF]
Yang F, Guo W, Sun S, Huang Y.
europepmc +1 more source
Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1. [PDF]
Nguyen PHA +10 more
europepmc +1 more source
Nomogram model of serum thymidine kinase 1 combined with ultrasonography for prediction of central lymph node metastasis risk in patients with papillary thyroid carcinoma pre-surgery. [PDF]
Song X +8 more
europepmc +1 more source
The role of serum thymidine kinase 1 activity in neoadjuvant-treated HER2-positive breast cancer: biomarker analysis from the Swedish phase II randomized PREDIX HER2 trial. [PDF]
Zhu Y +18 more
europepmc +1 more source
A Novel Model Using Serum Thymidine Kinase 1 and Low-dose Computed Tomography Parameters to Predict Three-year Lung Cancer Risk in People with Pulmonary Nodules: A Retrospective Study. [PDF]
Yao B +10 more
europepmc +1 more source
Mitochondrial Thymidine Kinase Inhibitors
Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.
María-Jesús, Pérez-Pérez +6 more
core +4 more sources
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Thymidine Kinase Diversity in Bacteria
Nucleosides, Nucleotides and Nucleic Acids, 2006Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related
Anders R Clausen +2 more
exaly +4 more sources

