Results 101 to 110 of about 5,593 (118)

Induction of thymidine phosphorylase by interferon and taxanes occurs only in human cancer cells with low thymidine phosphorylase activity

Cancer Letters, 2002
Thymidine phosphorylase (TP) regulates intracellular thymidine metabolism. It has been reported to be a prognostic factor for tumor angiogenesis and to activate some prodrugs of 5-fluorouracil (5-FU) to 5-FU. There is also evidence that TP is induced by interferons (IFNs) and xenobiotics, such as cyclophosphamide and taxanes, in experimental human ...
Wataru Ichikawa, Renzo Hirayama, Teiji Takechi, Masakazu Fukushima, Hiroyuki Okabe   +4 more
openaire   +3 more sources

Thymidine phosphorylase inhibits apoptosis induced by cisplatin

Biochemical and Biophysical Research Communications, 2003
An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-Deoxy-D-ribose, a degradation product of thymidine generated by TP, partially prevents hypoxia-induced apoptosis.
Yuich Nakajima, Tomohiro Noguchi, Masaki Kitazono, Tatsuhiko Furukawa, Ryuji Ikeda, Ryoichi Mitsuo, Xiao-Fang Che, Shin-ichi Akiyama, Shigeru Oiso, Hiroshi Uchimiya, Misako Haraguchi, Xiao Qin Ren, Tomoyuki Sumizawa, Ituro Inoue, Katsushi Yamada, Hiroshi Okumura   +15 more
openaire   +3 more sources

Detection of thymidine-phosphorylase in human blood platelets

Klinische Wochenschrift, 1973
Thymidine phosphorylase (thymidine: orthophosphate deoxyribosyltransferase, E.C.: 2.4.2.4.) was detected by thin layer chromatography using PEI cellulose plates in human blood platelets. At a final concentration of 5.6 × 10−5 M thymidine the enzyme activity attained 1 µMol per hour and 1011 platelets.
C. Doenecke, W. Schneider, P. G. Scheurlen   +2 more
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Purification of thymidine phosphorylase from human amniochorion

Biochimica et Biophysica Acta (BBA) - Enzymology, 1978
Thymidine phosphorylase (thymidine : orthophosphate deoxyribosyltransferase, EC 2.4.2.4) has been purified 1500-fold from extracts of human amniochorion. The purified enzyme catalyzes the phosphorolysis of deoxythymidine and to a lesser extent deoxyuridine but not deoxycytidine nor uridine.
Loretta D. Lee, Joseph Kubilus, Howard P. Baden   +2 more
openaire   +3 more sources

Catabolism of thymidine in human blood platelets purification and properties of thymidine phosphorylase

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1981
A pyrimidine nucleoside phosphorylase was partially purified from human blood platelets. The purified enzyme, as well as crude enzyme preparations, catalyses the phosphorolysis of thymidine and deoxyuridine, but not of uridine, and is able to catalyse direct pentosyl transfer from these deoxyribonucleosides to uracil or thymine; this enzyme has the ...
H. Bricaud, G. Razaka, Michel Rabaud, Claude Desgranges   +3 more
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Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase in Bladder Cancer

Urologia Internationalis, 2002
Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels in transitional cell carcinoma of the bladder resected from 38 patients were examined by ELISA. TP levels in high-grade and invasive cancer were significantly higher than those in low-grade and superficial cancer, respectively.
Tatsuo Iizumi, Kyouichi Hariu, Mika Sato, Hiroshi Tomomasa, Hirofumi Shimizu, Satoshi Sato, Takashi Umeda   +6 more
openaire   +3 more sources

The Role of Thymidine Phosphorylase in the Pathogenesis of Allergic Rhinitis

Acta Oto-Laryngologica, 2000
The activity and distribution of thymidine phosphorylase (TP) in the nasal mucosa of patients with nasal allergy was examined and compared with those in healthy subjects. TP activity was analyzed by spectrophotometry and expression was examined by immunoblotting and immunohistochemical staining using a monoclonal antibody specific to TP. The expression
Tomoyuki Sumizawa, Yuichi Kurono, Kazutaka Miyadera, Shoji Matsune, Tatsuhiko Furukawa, Kengo Nishimoto, Shin-ichi Akiyama, Yuji Takebayashi   +7 more
openaire   +2 more sources

Substrate specificity of Escherichia coli thymidine phosphorylase

Biochemistry (Moscow), 2007
Substrate specificity of Escherichia coli thymidine phosphorylase to thymidine derivatives modified at 5' -, 3' -, and 2' ,3' - positions of the sugar moiety was studied. Equilibrium and kinetic constants (K(m), K(I), k(cat)) of the phosphorolysis reaction have been determined for 20 thymidine analogs.
Cyrill S. Alexeev, Roman S. Esipov, E. V. Shcheveleva, Sergey N. Mikhailov, A. M. Kritzyn, A. S. Kuzmichov, N. G. Panova, Konstantin M. Polyakov, S. Gavryushov, A. I. Miroshnikov   +9 more
openaire   +3 more sources

HPLC-UV analysis of thymidine and deoxyuridine in plasma of patients with thymidine phosphorylase deficiency

Journal of Chromatography B, 2014
We present a simple, fast and validated method for the determination of the two nucleosides thymidine (dThd) and deoxyuridine (dUrd) in plasma of patients with symptoms suggestive of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), using high performance liquid chromatography coupled with ultraviolet spectrophotometric detection (HPLC-UV).
Mohamed, Susan, Caporali, Leonardo, DE GIORGIO, ROBERTO, CARELLI, VALERIO, CONTIN, MANUELA MARIA ANTONIA   +4 more
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Thymidine phosphorylase activity and angiogenesis in gastric cancer.

Oncology Reports, 1999
Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase).
Shunji Kohnoe, Hiromitsu Baba, Masaaki Tomoda, Akira Kabashima, Yoshihiro Kakeji, Shinya Oda, K. Sugimachi, T. Ooshiro, Yoshihiko Maehara   +8 more
openaire   +3 more sources