Results 101 to 110 of about 102,224 (277)

Thymidine phosphorylase expression and prognosis in colorectal cancer treated with 5-fluorouracil-based chemotherapy: A meta-analysis

Molecular and clinical oncology, 2017
In the past decades, various studies have suggested a possible link between thymidine phosphorylase (TP) level and colorectal cancer (CRC) treated with 5-fluorouracil (5-FU)-based chemotherapy; however, they have arrived at inconsistent results ...
J. Che, Lun Pan, Xiangling Yang, Zhiting Liu, Lanlan Huang, Chuangyu Wen, Aihua Lin, Huanliang Liu   +7 more
semanticscholar   +1 more source

Modeling and Optimization of Microwave Vacuum Drying for Pinelliae Rhizoma: Integrating Drying Kinetics, Artificial Neural Networks, and Quality Preservation

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The peeled Pinellia ternata (Thunb.) Breit tubers were dried with the microwave vacuum drying oven. Then, its drying characteristics, contents of nucleosides, and surface microstructural alterations of dried samples were determined, respectively. Drying parameters were predicted and optimized using four different mathematical models and artificial ...
Pan Wang, Xiaoping Yang, Xiaopeng Huang, Guojun Ma, Shidong Zhang, Siqi Wang, Ming Wang, Zewen Zhu, Yanrui Xu, ZePeng Zang, Xu Liu   +10 more
wiley   +1 more source

Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Nucleotides are the building blocks of DNA and RNA. They also play essential roles in various other biological processes, including protein glycosylation, ribosome biogenesis, and cytoskeletal function. The significance of the regulation of nucleotide metabolism has recently gained more attention in many physiological and pathological contexts,
Lara Dsouza, Zhilong Yang
wiley   +1 more source

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma [PDF]

Japanese Journal of Cancer Research, 1996
The activity of thymidine phosphorylase (dThdPase) has heen reported to increase in several types of malignant tumors. Experimental evidence has shown that dThdPase is identical to platelet‐derived endothelial cell growth factor, and that dThdPase has angiogenic activity.
Takebayashi, Yuji, Miyadera, Kazutaka, Akiyama, Shin‐ichi, Hokita, Shuichi, Yamada, Kazutaka, Akiba, Suminori, Yamada, Yuji, Sumizawa, Tomoyuki, Aikou, Takashi   +8 more
openaire   +2 more sources

Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection

OncoTarget, 2016
Systemic immune-inflammation index (SII), based on lymphocyte (L), neutrophil (N), and platelet (P) counts, was recently developed and reflects comprehensively the balance of host inflammatory and immune status.

semanticscholar   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

MedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang   +4 more
wiley   +1 more source

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59) [PDF]

, 2009
Thymidine phosphorylase (TP) is a catabolic enzyme in thymidine metabolism that is frequently upregulated in many solid tumors. Elevated TP levels are associated with tumor angiogenesis, metastasis and poor prognosis.
Aguado, L., Balzarini, Jan, Bronckaers, A., Camarasa Rius, María José, Gago Badenas, Federico, Liekens, S., Negri Martínez, Ana, Pérez Pérez, María Jesús   +7 more
core   +6 more sources

5-Fluorouracil degradation rate as a predictive biomarker of toxicity in breast cancer patients treated with capecitabine [PDF]

, 2020
Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging.
Botticelli, A., Cerbelli, B., Lionetto, L., Marchetti, P., Roberto, M., Scagnoli, S., Simmaco, M.   +6 more
core   +1 more source

Therapies for Mitochondrial Disease: Past, Present, and Future

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Mitochondrial disease is a diverse group of clinically and genetically complex disorders caused by pathogenic variants in nuclear or mitochondrial DNA‐encoded genes that disrupt mitochondrial energy production or other important mitochondrial pathways. Mitochondrial disease can present with a wide spectrum of clinical features and can often be
Megan Ball, Nicole J. van Bergen, Alison G. Compton, David R. Thorburn, Shamima Rahman, John Christodoulou   +5 more
wiley   +1 more source

Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma

Cancer Biology & Medicine, 2013
Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti ...
Dian-Jun Ye, Ji-Min Zhang
doaj   +1 more source