Results 91 to 100 of about 7,658 (197)
Cancer Biology & Medicine, 2013 Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti ...
Dian-Jun Ye, Ji-Min Zhang
doaj +1 more source
Thymine utilization in Escherichia coli K12. On the role of deoxyribose 1-phosphate and thymidine phosphorylase [PDF]
, 1973 Udgivelsesdato: December 1973Exogenously supplied thymine is only poorly utilized by wild-type cells of Escherichia coli for the synthesis of their DNA.
Nygaard, Per +2 more
core +1 more source
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase [PDF]
, 2004 A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase are described. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor. The scheme shows the
Stratford, Ian J. +5 more
core +1 more source
The diagnostic value of IL-6 and thymidine phosphorylase in the progression of osteosarcoma
Гений oртопедииIntroduction Thymidine phosphorylase (TP) is known to be correlated with the pathogenesis of solid tumors. IL-6 is overexpressed in osteosarcoma, and data exist showing that high concentrations of IL-6 are linked to a poor prognosis.
Bushra AM Abdul Azeez +3 more
doaj +1 more source
Diesterified derivatives of 5-iodo-2'-deoxyuridine as cerebral tumor tracers.
PLoS ONE, 2014 With the aim to develop beneficial tracers for cerebral tumors, we tested two novel 5-iodo-2'-deoxyuridine (IUdR) derivatives, diesterified at the deoxyribose residue.
Thomas W Rösler +8 more
doaj +1 more source
Thymidine phosphorylase: a possible marker of cell maturation in acute myeloid leukaemia. [PDF]
, 1980 Thymidine Phosphorylase activity has been measured in two populations of human Acute Myeloid Leukaemia cells (AML) and in normal human macrophages. During short-term culture in vitro of AML cells the activity of this enzyme increases progressively and ...
PALU', GIORGIO, Giorgio Palú
core +1 more source
Synthesis and Evaluation of Multisubstrate Bicyclic Pyrimidine Nucleoside Inhibitors of Human Thymidine Phosphorylase [PDF]
, 2016 A series of novel, multisubstrate, bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (TP) is described. Thymidine phosphorylase has been implicated in angiogenesis and plays a significant role in tumor progression and metastasis.
Patricia L. Gladstone (2512693) +11 more
core +1 more source
PLoS ONE, 2014 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive mitochondrial disease associated with mutations in the nuclear TYMP gene.
Elisa Boschetti +13 more
doaj +1 more source
Thymidine phosphorylase mutations cause instability of mitochondrial DNA [PDF]
, 2005 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder characterized by ptosis and progressive external ophthalmoplegia, peripheral neuropathy, severe gastrointestinal dysmotility, cachexia and ...
VALENTINO, MARIA LUCIA +4 more
core +1 more source