Results 81 to 90 of about 6,430 (168)

Efficacy of adeno-associated virus gene therapy in a MNGIE murine model enhanced by chronic exposure to nucleosides

EBioMedicine, 2020
Background: Preclinical studies have shown that gene therapy is a feasible approach to treat mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Ferran Vila-Julià, Raquel Cabrera-Pérez, Yolanda Cámara, Miguel Molina-Berenguer, Silvia Lope-Piedrafita, Michio Hirano, Federico Mingozzi, Javier Torres-Torronteras, Ramon Martí   +8 more
doaj   +1 more source

Synthesis, Characterization, and Bioactivity of Quinoxaline Thiazolotriazoles

Journal of Heterocyclic Chemistry, Volume 62, Issue 11, Page 1698-1707, November 2025.
Quinoxaline thiazolotriazole target molecules with antibacterial, antitubercular and antidiabetic activity. ABSTRACT A total of 10 quinoxaline thiazolo[2,3‐c][1,2,4]triazole hybrid molecules were synthesized in a four‐step synthetic protocol. Six of these compounds are reported here for the first time.
Silungile Mhlongo, Sibusiso Senzani, Shahidul Islam, Kolawole Olofinsan, Moganavelli Singh, Nirasha Nundkumar, Sithabile Mokoena, Rajshekhar Karpoormath, Neil A. Koorbanally   +8 more
wiley   +1 more source

Efficient Expression of Soluble Recombinant Protein Fused with Core-Streptavidin in Bacterial Strain with T7 Expression System

Methods and Protocols, 2020
The limited amount of fusion protein transported into cytosol milieu has made it challenging to obtain a sufficient amount for further applications. To avoid the laborious and expensive task, T7 promoter-driving pET-30a(+) coding for chimeric gene of ...
Ammar Tarar, Esmael M. Alyami, Ching-An Peng   +2 more
doaj   +1 more source

The diagnostic value of IL-6 and thymidine phosphorylase in the progression of osteosarcoma

Гений oртопедии
Introduction Thymidine phosphorylase (TP) is known to be correlated with the pathogenesis of solid tumors. IL-6 is overexpressed in osteosarcoma, and data exist showing that high concentrations of IL-6 are linked to a poor prognosis.
Bushra AM Abdul Azeez, Ghufran Salman Abd Alhussain, Rabab Alhosainy Salman, Ali A. Al-Fahham   +3 more
doaj   +1 more source

Liver as a source for thymidine phosphorylase replacement in mitochondrial neurogastrointestinal encephalomyopathy.

PLoS ONE, 2014
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive mitochondrial disease associated with mutations in the nuclear TYMP gene.
Elisa Boschetti, Roberto D'Alessandro, Francesca Bianco, Valerio Carelli, Giovanna Cenacchi, Antonio D Pinna, Massimo Del Gaudio, Rita Rinaldi, Vincenzo Stanghellini, Loris Pironi, Kerry Rhoden, Vitaliano Tugnoli, Carlo Casali, Roberto De Giorgio   +13 more
doaj   +1 more source

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn’s disease

BMC Gastroenterology, 2019
Background Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn’s disease based upon clinical, imaging and pathological findings ...
Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery, Oscar Swift   +5 more
doaj   +1 more source

Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

Case Reports in Anesthesiology, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP).
Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan   +3 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source

Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction. [PDF]

J Am Heart Assoc, 2023
Du L, Yue H, Rorabaugh BR, Li OQY, DeHart AR, Toloza-Alvarez G, Hong L, Denvir J, Thompson E, Li W.   +9 more
europepmc   +1 more source