Results 81 to 90 of about 7,658 (197)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants [PDF]

, 2005
Thymidine phosphorylase (EC 2.4.2.4) catalyses the reversible phosphorolysis of pyrimidine 2′-deoxynucleosides, forming 2-deoxyribose-1-phosphate and pyrimidine.
Edwards, PN, Freeman, Sally; id_orcid, Jaffar, Mohammed, Reigan, P, Gbaj, A, Gbaj, Abdul, Reigan, Philip, Douglas, Kenneth T.; id_orcid, Freeman, S; id_orcid, Edwards, Philip N., Jaffar, M, Douglas, KT.; id_orcid   +11 more
core   +1 more source

Wernicke Encephalopathy Complicating a Distinctive POLG Phenotype With MNGIE‐Like Features

European Journal of Neurology, Volume 33, Issue 3, March 2026.
ABSTRACT Background Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an extremely rare autosomal recessive disease caused by variants in the thymidine phosphorylase gene (TYMP), primarily characterized by severe gastrointestinal and neurological symptoms.
Giuliana Capece, Luca Caumo, Sara Volta, Pietro Riguzzi, Elena Sogus, Angela Petrosino, Sara Vianello, Daniele Sabbatini, Leonardo Salviati, Renzo Manara, Carlo Viscomi, Gianni Sorarù, Luca Bello, Elena Pegoraro   +13 more
wiley   +1 more source

Effect of Renal Impairment on the Pharmacokinetics and Safety of Doxecitine and Doxribtimine: A Single‐Dose Phase 1 Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract This Phase 1 study investigated the pharmacokinetics and safety of a single dose of the FDA‐approved doxecitine and doxribtimine (266.6 mg/kg; 133.3 mg/kg of deoxycytidine [dC] and deoxythymidine [dT]) in participants with severe (n = 8) or moderate (n = 8) renal impairment (estimated glomerular filtration rate [eGFR] 15–29 mL/min/1.73 m2 and ...
Aravind Mittur, Susan A. VanMeter
wiley   +1 more source

Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing Thymidine Phosphorylase [PDF]

International audiencePyrimidine analogs are part of the first-line chemotherapy regimen for gastrointestinal cancers. Trifluridine combined with tipiracil, a specific thymidine phosphorylase inhibitor, in TAS-102 has recently emerged as a potential ...
Laverriere, Marie-Hélène, Yakoubi, Malika, Thomas, Fabienne, Bellaud, Pascale, Josserand, Véronique, Roth, Gael, S, Girard, Edouard, Henry, Maxime, Sébillot, Anthony, Malier, Marie, Arellano, Cécile, Millet, Arnaud   +11 more
core   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Elevated Thymidine Phosphorylase Activity in Psoriatic Lesions Accounts for the Apparent Presence of an Epidermal “Growth Inhibitor,” But Is Not in Itself Growth Inhibitory [PDF]

, 1991
An apparent tissue-specific growth inhibitor, or chalone, obtained from psoriatic lesions was tentatively identified in the 100-kDa fraction based upon inhibition of DNA synthesis, as measured by [3H]-thymidine uptake by a squamous cell carcinoma cell ...
Hammerberg, Craig, Kevin D Cooper, Voorhees, John J, Cooper, Kevin D, Gary J Fisher, Craig Hammerberg, John J Voorhees, Fisher, Gary J   +7 more
core   +1 more source

Organ‐Specific Histopathological Effects of Prenatal Alcohol Exposure: A Narrative Review

Congenital Anomalies, Volume 66, Issue 1, January/December 2026.
ABSTRACT The role of alcohol‐induced epigenetic modifications that predispose the fetus to metabolic dysregulation, increased susceptibility to future substance use, and long‐term behavioral and cognitive impairments has received increasing attention.
Rana Nur Gursu, Dilan Cetinavci, Hulya Elbe   +2 more
wiley   +1 more source

Anthracyclines and taxanes induce the upregulation of thymidine phosphorylase in breast cancer cells [PDF]

, 2007
We have investigated the immunohistochemical expression of thymidine phosphorylase before and after the administration of anthracycline, and/or anthracycline/taxane-based preoperative chemotherapy in a consecutive series of 55 patients with primary ...
MANSUTTI M, PUGLISI, Fabio, DI LORETO, Carla, PIZZOLITTO S, MINISINI AM, ANDREETTA C, VALENT F, CARDELLINO G, RUSSO S, RIJAVEC E   +9 more
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