Results 61 to 70 of about 7,658 (197)

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma [PDF]

Japanese Journal of Cancer Research, 1996
The activity of thymidine phosphorylase (dThdPase) has heen reported to increase in several types of malignant tumors. Experimental evidence has shown that dThdPase is identical to platelet‐derived endothelial cell growth factor, and that dThdPase has angiogenic activity.
Takebayashi, Yuji, Miyadera, Kazutaka, Akiyama, Shin‐ichi, Hokita, Shuichi, Yamada, Kazutaka, Akiba, Suminori, Yamada, Yuji, Sumizawa, Tomoyuki, Aikou, Takashi   +8 more
openaire   +2 more sources

The Expression Level of Human Thymidine Phosphorylase in Urinary Tract Cancer [PDF]

, 1998
Human thymidine phosphorylase (dThdPase) catalyses reversible phosphorylation of thymidine to deoxyribose-1- phosphate and thymine, and is identical to Platelet-derived endothelial cell growth factor (PD-ECGF), which is an angiogenic factor purified from
Sawase, Kenji
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Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE) [PDF]

, 2002
We report the presence of the unusual nucleoside deoxyuridine in the urine of a patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) (MIM 603041) due to thymidine phosphorylase (TP:EC 2.4.2.4) deficiency.
S. R. Hammans, Hammans, SR, Duley, J.A., Carrey, E.A., Carrey, EA, E. A. Carrey, Fairbanks, LD, J. A. Duley, Marinaki, AM, Hammans, S.R., Duley, JA, Fairbanks, L.D., A. M. Marinaki, Marinaki, A.M., L. D. Fairbanks   +14 more
core   +1 more source

Enzyme Inhibitory and Anti-cancer Properties of Moringa peregrina

Vitae
Background: Moringa peregrina is widely used in the traditional medicine of the Arabian Peninsula to treat various ailments, because it has many pharmacologically active components with several therapeutic effects.
Shaymaa
doaj   +1 more source

Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton.

Biological and Pharmaceutical Bulletin, 2001
Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a more potent inhibitor than the classical inhibitor, 5 ...
KITA, Tetsuya, TAKAHASHI, Hiroyasu, HASHIMOTO, Yuichi   +2 more
openaire   +3 more sources

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Leukoencephalopathy in mitochondrial neurogastrointestinal encephalomyopathy-like syndrome with polymerase-gamma mutations

Annals of Indian Academy of Neurology, 2019
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) syndrome, caused by mutations in the thymidine phosphorylase gene, manifests as a multisystemic disorder characterized by severe gastrointestinal dysmotility, cachexia, ptosis and ...
Hongyan Huang, Xinglong Yang, Ling Liu, Yanming Xu   +3 more
doaj   +1 more source

Fruquintinib Plus TAS‐102 With or Without SBRT as Third‐ Or Later‐Line Therapy for Metastatic Colorectal Cancer: Preliminary Results From a Prospective Phase II Trial

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Both fruquintinib and TAS‐102 monotherapies are guideline‐recommended for third‐line treatment of metastatic colorectal cancer (mCRC). This study aimed to analyze the preliminary outcomes of fruquintinib combined with TAS‐102, with or without stereotactic body radiation therapy (SBRT), as a third‐ or later‐line therapy for mCRC.
Yi Wang, Jianfen Xu, Linchun Liang, Yunjie Chen, Leizheng Fei, Jing Hu, Jianjiong Li, Yi Lu, Feng Ren, Ke Chen, Yanping Shen, Qingsong Tao, Zhi Fang, Kaitai Liu, Hua Ye, Jing Zhang, Yunbao Xu, Haoxun Mao, Chen Zhang, Chuangzhou Rao   +19 more
wiley   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

The prognostic and therapeutic significance of biological molecular markers in human anorectal carcinomas treated with 5'fluorouracil chemoradiation. [PDF]

, 2005
Advances in tumour biology have led to studies of new biological markers, which may predict treatment response and clinical outcome independently of standard clinicopathological variables.
Mawdsley, S.K.V.
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