Results 41 to 50 of about 7,658 (197)

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors

Pharmaceuticals, 2023
The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death ...
Davinder Kumar, Navidha Aggarwal, Aakash Deep, Harsh Kumar, Hitesh Chopra, Rakesh Kumar Marwaha, Simona Cavalu   +6 more
doaj   +1 more source

Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]

Journal of Biological Chemistry, 2002
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A, MARTI R, NISHINO I, ANDREU AL, NAINI A, TADESSE S, PELA, IVANA, ZAMMARCHI, ENRICO, DONATI MA, OLIVER JA, HIRANO M.   +10 more
openaire   +6 more sources

Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features

Patologìâ, 2015
The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate
E. M. Bakurova, R. V. Buzina, R. B. Kondratiuk, Yu. K. Gulkov, I. V. Vasilenko, B. G. Borzenko   +5 more
doaj   +1 more source

Clinicopathology and Diagnosis Delay in a 40-Year-Old with Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE)

Case Reports in Gastroenterology, 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive and fatal multisystem metabolic disorder. It presents with wide-ranging gastrointestinal and neurologic symptoms.
Antonios Tawk, Mohammed Hussein Kamarreddine, Mona Dagher, Ghadi Abboud, Mohamad Chams, Fatmeh Ghandour-Hajj, Mounir Khoury, Said Farhat   +7 more
doaj   +1 more source

Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18. [PDF]

, 2019
Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18.
M. Iqbal Choudhary (598049), Sumaira Javaid (7886897), Muniza Shaikh (7886900), Narjis Fatima (3778390)   +3 more
core   +1 more source

Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase [PDF]

Journal of the American Chemical Society, 2010
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, and its action promotes angiogenesis. In the absence of phosphate, hTP catalyzes a slow hydrolytic depyrimidination of dT yielding thymine and 2-deoxyribose (dRib).
Phillip A, Schwartz, Mathew J, Vetticatt, Vern L, Schramm   +2 more
openaire   +2 more sources

Clinical spectrum of early onset “Mediterranean” (homozygous p.P131L mutation) mitochondrial neurogastrointestinal encephalomyopathy

JIMD Reports, 2022
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive mitochondrial disorder characterized by cumulative and progressive gastrointestinal and neurological findings.
Sema Kalkan Uçar, Havva Yazıcı, Ebru Canda, Esra Er, Fatma Derya Bulut, Cenk Eraslan, Hüseyin Onay, Bridget Elizabeth Bax, Mahmut Çoker   +8 more
doaj   +1 more source

Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the association between thymidine phosphorylase(TYMP) polymorphism and clinical outcomes of colorectal cancer(CRC) patients received adjuvant chemotherapy after R0 resection.
ZHANG Yu, HOU Yanhua, ZHANG Dezhi
doaj   +1 more source

In-vitro thymidine phosphorylase inhibitory activities of 4-hydroxylbenzohydarazides (1–29). [PDF]

, 2020
In-vitro thymidine phosphorylase inhibitory activities of 4-hydroxylbenzohydarazides (1–29).
Rizwana Malik (8363277), M. Iqbal Choudhary (598049), Sumaira Javaid (7886897), Humaira Zafar (5331716), Syed Muhammad Saad (8338323), Atta-ur Rahman (613610), Khalid Mohammed Khan (2854526)   +6 more
core   +1 more source

Data on proteome of Mycoplasma hominis cultivated with arginine or thymidine as a carbon source

Data in Brief, 2020
Mycoplasma hominis is an opportunistic bacterium that can cause acute and chronic infections of the urogenital tract. This bacterium, like all other Mycoplasma species, is characterized by the reduced genome size, and, consequently, reduction of the main
Tatiana A. Semashko, Daria V. Evsyutina, Valentina G. Ladygina, Aleksandr I. Zubov, Irina V. Rakovskaya, Sergey I. Kovalchuk, Rustam H. Ziganshin, Olga V. Pobeguts   +7 more
doaj   +1 more source