Results 41 to 50 of about 6,430 (168)

Mycoplasma PneumoniaeThymidine Phosphorylase

Nucleosides, Nucleotides and Nucleic Acids, 2014
Mycoplasma pneumoniae (Mpn) is a human pathogen causing acute respiratory diseases and accounts for approximately 30% cases of community-acquired pneumonia. Co-infection with Mycoplasmas compromises the efficacy of anticancer and antiviral nucleoside analog-based drugs due to the presence of Mycoplasma thymidine phosphorylase (TP).
Wang, L., Schmidl, Sebastian R., Stuelke, Joerg   +2 more
openaire   +3 more sources

Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features

Patologìâ, 2015
The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate
E. M. Bakurova, R. V. Buzina, R. B. Kondratiuk, Yu. K. Gulkov, I. V. Vasilenko, B. G. Borzenko   +5 more
doaj   +1 more source

Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]

Journal of Biological Chemistry, 2002
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A, MARTI R, NISHINO I, ANDREU AL, NAINI A, TADESSE S, PELA, IVANA, ZAMMARCHI, ENRICO, DONATI MA, OLIVER JA, HIRANO M.   +10 more
openaire   +6 more sources

Clinicopathology and Diagnosis Delay in a 40-Year-Old with Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE)

Case Reports in Gastroenterology, 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive and fatal multisystem metabolic disorder. It presents with wide-ranging gastrointestinal and neurologic symptoms.
Antonios Tawk, Mohammed Hussein Kamarreddine, Mona Dagher, Ghadi Abboud, Mohamad Chams, Fatmeh Ghandour-Hajj, Mounir Khoury, Said Farhat   +7 more
doaj   +1 more source

Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]

Biochemical Pharmacology, 2010
Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V., Azijli, K., Jansen, E.E.W., Wamelink, M.M.C., Jakobs, C., Struijs, E.A., Fukushima, M, Kruyt, F.A.E., Peters, G.J.   +8 more
openaire   +6 more sources

Clinical spectrum of early onset “Mediterranean” (homozygous p.P131L mutation) mitochondrial neurogastrointestinal encephalomyopathy

JIMD Reports, 2022
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive mitochondrial disorder characterized by cumulative and progressive gastrointestinal and neurological findings.
Sema Kalkan Uçar, Havva Yazıcı, Ebru Canda, Esra Er, Fatma Derya Bulut, Cenk Eraslan, Hüseyin Onay, Bridget Elizabeth Bax, Mahmut Çoker   +8 more
doaj   +1 more source

Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase [PDF]

Journal of the American Chemical Society, 2010
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, and its action promotes angiogenesis. In the absence of phosphate, hTP catalyzes a slow hydrolytic depyrimidination of dT yielding thymine and 2-deoxyribose (dRib).
Phillip A, Schwartz, Mathew J, Vetticatt, Vern L, Schramm   +2 more
openaire   +2 more sources

Influence of TYMP Polymorphism on Clinical Outcomes of Colorectal Cancer Patients Received Adjuvant Chemotherapy After R0 Resection

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the association between thymidine phosphorylase(TYMP) polymorphism and clinical outcomes of colorectal cancer(CRC) patients received adjuvant chemotherapy after R0 resection.
ZHANG Yu, HOU Yanhua, ZHANG Dezhi
doaj   +1 more source

Mitochondrial neurogastrointestinal encephalomyopathy in a Pakistani female: a case report 

Journal of Medical Case Reports, 2022
Background Mitochondrial neurogastrointestinal encephalopathy is a rare multisystem autosomal recessive disease caused by mutations in the TYMP gene, that encodes for thymidine phosphorylase.
Zaraq Rashid Khan, Alvina Karam, Mian Ayaz ul Haq, Aleena Aman, Ahmad Sharjeel Karam   +4 more
doaj   +1 more source

Data on proteome of Mycoplasma hominis cultivated with arginine or thymidine as a carbon source

Data in Brief, 2020
Mycoplasma hominis is an opportunistic bacterium that can cause acute and chronic infections of the urogenital tract. This bacterium, like all other Mycoplasma species, is characterized by the reduced genome size, and, consequently, reduction of the main
Tatiana A. Semashko, Daria V. Evsyutina, Valentina G. Ladygina, Aleksandr I. Zubov, Irina V. Rakovskaya, Sergey I. Kovalchuk, Rustam H. Ziganshin, Olga V. Pobeguts   +7 more
doaj   +1 more source