Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE [PDF]
Molecular Therapy: Methods & Clinical Development, 2020 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal metabolic disorder caused by thymidine phosphorylase (TP) deficiency. Successful therapeutic interventions for this disease rely on a means for efficient and long-lasting ...
Marjolein Meinders +5 more
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The cytosol activity of thymidine phosphorylase in endometrial cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2008 Background Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor samples from patients with ...
Bieńkiewicz Andrzej +3 more
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Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE [PDF]
Journal of Translational MedicineInherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Jixiang Du +7 more
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Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study [PDF]
Molecules, 2019 We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7 ...
Noor Barak Almandil +11 more
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Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase. [PDF]
PLoS ONE, 2018 Thymidine phosphorylase (TP; EC 2.4.2.4) is involved regulation of intra- or extracellular thymidine concentration, angiogenesis, cancer chemotherapy, radiotherapy, as well as tumor imaging.
Taesung Oh, Mahmoud H El Kouni
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Molecular Genetics and Metabolism Reports, 2022 We describe the case of a Greek female patient with the Classic form of the ultra- rare and fatal autosomal recessive disorder Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) and the impact of allogeneic hematopoietic stem cell ...
A. Paisiou +16 more
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Thymidine phosphorylase and uridine phosphorylase of Lactobacillus casei [PDF]
FEMS Microbiology Letters, 1988 Crude extracts of Lactobacillus casei, were found to possess both thymidine phosphorylase and uridine phosphorylase activities, which were associated with a single sucrose gradient band. However, using dye ligand chromatography (Green A), two enzymatic fractions were obtained each of which possessed mainly one of these activities.
Y. Avraham, J. Yashphe, N. Grossowicz
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Safety and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase in Mitochondrial Neurogastrointestinal Encephalomyopathy [PDF]
Journal of Clinical Medicine, 2019 Michelle Levene +2 more
exaly +2 more sources
Molecular Therapy: Methods & Clinical Development, 2018 Erythrocyte encapsulated thymidine phosphorylase is recombinant Escherichia coli thymidine phosphorylase encapsulated within human autologous erythrocytes and is under development as an enzyme replacement therapy for the ultra-rare inherited metabolic ...
Michelle Levene +5 more
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TYMP (thymidine phosphorylase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TYMP (thymidine phosphorylase), with data on DNA, on the protein encoded, and where the gene is implicated.
Bijnsdorp, IV, Peters, GJ
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