Results 21 to 30 of about 7,658 (197)
Molecular Genetics & Genomic MedicineBackground Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, which disrupt thymidine metabolism.
Ling Li +6 more
doaj +2 more sources
Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]
Biochemical Pharmacology, 2010 Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V. +8 more
openaire +9 more sources
Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE [PDF]
Journal of Translational MedicineInherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Jixiang Du +7 more
doaj +2 more sources
Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study [PDF]
Molecules, 2019 We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7 ...
Noor Barak Almandil +11 more
doaj +2 more sources
Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase. [PDF]
PLoS ONE, 2018 Thymidine phosphorylase (TP; EC 2.4.2.4) is involved regulation of intra- or extracellular thymidine concentration, angiogenesis, cancer chemotherapy, radiotherapy, as well as tumor imaging.
Taesung Oh, Mahmoud H El Kouni
doaj +2 more sources
A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow. [PDF]
Catal Sci Technol, 2022 Four pharmaceutically relevant nucleoside analogues (5-fluoro-2’-deoxyuridine, 5-chloro-2’-deoxyuridine, 5-bromo-2’-deoxyuridine, and 5-iodo-2’-deoxyuridine) have been synthesized by using a novel thymidine phosphorylase from H.
Benítez-Mateos AI +3 more
europepmc +2 more sources
Molecular Genetics and Metabolism Reports, 2022 We describe the case of a Greek female patient with the Classic form of the ultra- rare and fatal autosomal recessive disorder Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) and the impact of allogeneic hematopoietic stem cell ...
A. Paisiou +16 more
doaj +1 more source
Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18 (Continued). [PDF]
, 2019 Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18 (Continued).
M. Iqbal Choudhary (598049) +3 more
core +5 more sources
Thymidine phosphorylase and uridine phosphorylase of Lactobacillus casei [PDF]
FEMS Microbiology Letters, 1988 Crude extracts of Lactobacillus casei, were found to possess both thymidine phosphorylase and uridine phosphorylase activities, which were associated with a single sucrose gradient band. However, using dye ligand chromatography (Green A), two enzymatic fractions were obtained each of which possessed mainly one of these activities.
Y. Avraham, J. Yashphe, N. Grossowicz
openaire +2 more sources
BMC Cancer, 2011 Background To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Shen Lin +4 more
doaj +1 more source