Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and molecular docking study [PDF]
Saudi Pharmaceutical Journal, 2023 Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development, invasion and metastasis of tumors as well as angiogenesis. In our current research, we examine how structurally changing bis-thiadiazole bearing bis-schiff bases ...
Rafaqat Hussain +12 more
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Eradication of Cancer Cells Using Doxifluridine and Mesenchymal Stem Cells Expressing Thymidine Phosphorylase [PDF]
BioengineeringGene-directed enzyme prodrug therapy (GDEPT) has been developed over several decades as a targeted cancer treatment aimed at minimizing toxicity to healthy cells. This approach involves three key components: a non-toxic prodrug, a gene encoding an enzyme
Xutu Wang, Ian Peng, Ching-An Peng
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Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction [PDF]
Cell Death and Disease, 2023 Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer, atherosclerosis and obesity.
Adrian Baris +4 more
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Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking [PDF]
Molecules, 2023 Overexpression of the thymidine phosphorylase (TP) enzyme induces angiogenesis, which eventually leads to metastasis and tumor growth. The crucial role of TP in cancer development makes it an important target for anticancer drug discovery.
Tian-Meng Cui +11 more
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Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development [PDF]
Frontiers in ImmunologyBackgroundCOVID-19 survivors exhibit increased interstitial lung fibrosis, a known risk factor for lung cancer. We investigated whether SARS-CoV-2 spike protein (SP)-induced lung injury and elevated thymidine phosphorylase (TYMP) promote lung ...
Cayleigh Wallace +6 more
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Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: An insight to experimental, in-vitro biological potential and computational approaches [PDF]
Saudi Pharmaceutical JournalIn this study, a series of newly synthesized indazole-based thiadiazole hybrid derivatives (1–13) were successfully synthesized from indazole-based thiosemicarbazides starting from the 5-methyl-1H-indazole-3-carboxylic acid.
Sabeen Arshad +6 more
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Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner [PDF]
Frontiers in Medicine, 2021 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is a human respiratory disease. Hitherto, there is no effective treatment has been established.
Wei Li, Hong Yue
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European Journal of Pharmacology, 2004 Thymidine phosphorylase (platelet-derived-endothelial-cell-growth-factor) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate, activates 5'-deoxy-5-fluorouridine (5'DFUR) and inactivates trifluorothymidine (TFT).
Kees Smid +2 more
exaly +6 more sources
Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies. [PDF]
PLoS ONE, 2020 Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation.
Sumaira Javaid +6 more
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Thymidine phosphorylase in cancer aggressiveness and chemoresistance
Pharmacological Research, 2018 Thymidine phosphorylase (TP) is a rate-limiting enzyme in thymidine catabolism. TP has several important roles in biological and pharmacological mechanisms; importantly TP acts as an angiogenic factor and one of metabolic enzymes of fluoro-pyrimidine anticancer agents and modifies inflammation.
Tatsuhiko Furukawa +2 more
exaly +3 more sources