Effect of aquatic extracts of oleander and Melia azedarach on the nucleic acid content of trichomonas vaginalis in vivo [PDF]
مجلة التربية والعلم, 2007 This study was conducted to elucidate the effect of aqueous leaf extractof Nerium oleander and fruit extract of Melia azedarach on nucleic acidscontent and activity of some enzymes in Trichomonas vagina/is whichgrowth in Diamond's medium tryptone, yeast ...
Rana Abdullah, Hussain Artain
doaj +1 more source
Assessment of Thymidine Phosphorylase Function: Measurement of Plasma Thymidine (and Deoxyuridine) and Thymidine Phosphorylase Activity [PDF]
, 2011 We describe detailed methods to measure thymidine (dThd) and deoxyuridine (dUrd) concentrations and thymidine phosphorylase (TP) activity in biological samples. These protocols allow the detection of TP dysfunction in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Martí R, López LC, Hirano M.
openaire +2 more sources
Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]
, 2013 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bax, BE +13 more
core +1 more source
Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase [PDF]
, 2016 Thymidine phosphorylase plays an important role in angiogenesis, which is an attractive target for therapy of cancer and other diseases. In our continuous effort to develop novel inhibitors of thymidine phosphorylase, we have discovered that 6 ...
Radim Nencka (808341) +7 more
core +7 more sources
Thymidine phosphorylase in cancer; Enemy or friend? [PDF]
, 2016 Thymidine phosphorylase (TP) is a nucleoside metabolism enzyme that plays an important role in the pyrimidine pathway.TP catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Although this reaction is reversible,
Osman, Nemer +4 more
core +1 more source
Hematology/Oncology and Stem Cell Therapy, 2015 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder. The mutation in the ECGF1 gene causes severe deficiency of thymidine phosphorylase (TP), which in turn increases thymidine and deoxyuridine in the blood,
Musthafa Chalikandy Peedikayil +4 more
doaj +1 more source
Kinetic studies of most active compounds on thymidine phosphorylase. [PDF]
, 2020 Kinetic studies of most active compounds on thymidine phosphorylase.
Rizwana Malik (8363277) +6 more
core +1 more source
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival
Cell Reports, 2017 Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata +20 more
doaj +1 more source
Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer
Current Issues in Pharmacy and Medical Sciences, 2013 Patients with cancer of stomach, colon cancer and rectum showed an increase in the thymidine kinase, 5'–nucleotidase of adenylate, adenosine deaminase activities and a decrease in the thymidine phosphorylase activity, which can cause DNA biosynthesis ...
Berta Borzenko +2 more
doaj +1 more source
BMC Cancer, 2008 Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V +4 more
doaj +1 more source