Results 31 to 40 of about 6,430 (168)

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

BMC Cancer, 2010
Background Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics.
You Young, Kim Dong-Goo, Chung Eun-Seon, Lee Myung, Won Hye, Hong Tae, Lee In-Seok   +6 more
doaj   +1 more source

Effect of aquatic extracts of oleander and Melia azedarach on the nucleic acid content of trichomonas vaginalis in vivo [PDF]

مجلة التربية والعلم, 2007
This study was conducted to elucidate the effect of aqueous leaf extractof Nerium oleander and fruit extract of Melia azedarach on nucleic acidscontent and activity of some enzymes in Trichomonas vagina/is whichgrowth in Diamond's medium tryptone, yeast ...
Rana Abdullah, Hussain Artain
doaj   +1 more source

Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel

BMC Cancer, 2011
Background To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Shen Lin, Li Yan-yan, Yu Jing-wei, Lu Ming, Gao Jing   +4 more
doaj   +1 more source

Assessment of Thymidine Phosphorylase Function: Measurement of Plasma Thymidine (and Deoxyuridine) and Thymidine Phosphorylase Activity [PDF]

, 2011
We describe detailed methods to measure thymidine (dThd) and deoxyuridine (dUrd) concentrations and thymidine phosphorylase (TP) activity in biological samples. These protocols allow the detection of TP dysfunction in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Martí R, López LC, Hirano M.
openaire   +2 more sources

Mitochondrial Neurogastrointestinal Encephalomyopathy Treated with Stem Cell Transplantation: A Case Report and Review of Literature

Hematology/Oncology and Stem Cell Therapy, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder. The mutation in the ECGF1 gene causes severe deficiency of thymidine phosphorylase (TP), which in turn increases thymidine and deoxyuridine in the blood,
Musthafa Chalikandy Peedikayil, Eje Ingvar Kagevi, Ehab Abufarhaneh, Moeenaldeen Dia Alsayed, Hazzaa Abdulla Alzahrani   +4 more
doaj   +1 more source

Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome

Advances in Hematology, 2011
Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or Sézary ...
Xingcao Nie, Rekha Bhat, Essel Dulaimi Al-Saleem, Eric C. Vonderheid, J. Steve Hou   +4 more
doaj   +1 more source

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

Cell Reports, 2017
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama   +20 more
doaj   +1 more source

Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer

Clinical Medicine Insights: Oncology, 2012
Background The thymidine phosphorylase (TP) enzyme has several tumor-promoting functions. The aim of this study was to explore TP gene expression in relation to clinical and histopathological data obtained from patients with stage III colorectal cancer ...
Elinor B. Lindskog, Yvonne Wettergren, Elisabeth Odin, Bengt Gustavsson, Kristoffer Derwinger   +4 more
doaj   +2 more sources

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors

Pharmaceuticals, 2023
The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death ...
Davinder Kumar, Navidha Aggarwal, Aakash Deep, Harsh Kumar, Hitesh Chopra, Rakesh Kumar Marwaha, Simona Cavalu   +6 more
doaj   +1 more source

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

BMC Cancer, 2008
Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V, Danenberg Kathleen, Uetake Hiroyuki, Makino Hiroshi, Sugihara Kenichi   +4 more
doaj   +1 more source