Results 51 to 60 of about 6,430 (168)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives

Journal of Chemistry, 2016
A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood   +9 more
doaj   +1 more source

Transition State Analysis of the Arsenolytic Depyrimidination of Thymidine by Human Thymidine Phosphorylase [PDF]

Biochemistry, 2011
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, promotes angiogenesis, and is involved in metabolic inactivation of antiproliferative agents that inhibit thymidylate synthase. Understanding its transition state structure is on the path to design transition state analogues.
Phillip A, Schwartz, Mathew J, Vetticatt, Vern L, Schramm   +2 more
openaire   +2 more sources

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis

Case Reports in Neurology, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Mauro Scarpelli, Anna Russignan, Melinda Zombor, Csaba Bereczki, Francesca Zappini, Romina Buono, Bridget E. Bax, Alessandro Padovani, Paola Tonin, Massimiliano Filosto   +9 more
doaj   +1 more source

Real‐World Efficacy of Metronomic Chemotherapy in Advanced Breast Cancer Across Molecular Subtypes

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective Metronomic chemotherapy (mCHT) is widely used in the treatment of breast cancer due to its low toxicity and convenience. However, there remain real‐world studies with satisfactory samples focusing on mCHT in advanced breast cancer. Methods Enrolled patients were assigned into capecitabine‐based (X‐based) group and other mCHT group ...
Hanxing Zhou, Linmin Chen, Qianyi Lu, Huailiang Wu, Kuikui Jiang, Fei Xu, Shusen Wang   +6 more
wiley   +1 more source

Lipid Peroxidation and Thymidine Phosphorylase expression in Prostate Carcinoma [PDF]

Journal of Stress Physiology & Biochemistry, 2012
Aim: To understand the association between markers of oxidative stress and angiogenesis in relation to disease progression, clinical stage and cytological grade in patho-physiology of prostate carcinoma.Patients and Methods: Case control study comprised ...
Tandon R., U.S. Rath, Deepti Pande, Reena Negi, Kanchan Karki, Hari D. Khanna   +5 more
doaj  

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy

MedComm, Volume 7, Issue 6, June 2026.
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma, Qing Wang, Yusheng Zhang, Yang Li, Hongwei Wu, Hongjun Yang, Xianyu Li   +6 more
wiley   +1 more source

Enzyme Inhibitory and Anti-cancer Properties of Moringa peregrina

Vitae
Background: Moringa peregrina is widely used in the traditional medicine of the Arabian Peninsula to treat various ailments, because it has many pharmacologically active components with several therapeutic effects.
Shaymaa
doaj   +1 more source

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma [PDF]

Japanese Journal of Cancer Research, 1996
The activity of thymidine phosphorylase (dThdPase) has heen reported to increase in several types of malignant tumors. Experimental evidence has shown that dThdPase is identical to platelet‐derived endothelial cell growth factor, and that dThdPase has angiogenic activity.
Takebayashi, Yuji, Miyadera, Kazutaka, Akiyama, Shin‐ichi, Hokita, Shuichi, Yamada, Kazutaka, Akiba, Suminori, Yamada, Yuji, Sumizawa, Tomoyuki, Aikou, Takashi   +8 more
openaire   +2 more sources