Results 101 to 110 of about 7,658 (197)

The thymidine phosphorylase inhibitor 5′-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist [PDF]

, 2013
5′-O-Tritylinosine (KIN59) is an allosteric inhibitor of the angiogenic enzyme thymidine phosphorylase. Previous observations showed the capacity of KIN59 to abrogate thymidine phosphorylase-induced as well as developmental angiogenesis in the chicken ...
Liekens, S., Belleri, M., Gigante, Alba, Peréz-Pérez, María-Jesús, Nico, B., Casanova, Elena, Bronckaers, A., Opdenakker, Ghislain, Ribatti, Domenico, Sienaert, R., Balzarini, Jan, Bugatti, A., Presta, M.   +12 more
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Interdomain twists of human thymidine phosphorylase and its active–inactive conformations: Binding of 5‐FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase [PDF]

, 2019
5‐fluorouracil (5‐FU) is an anticancer drug, which inhibits human thymidine phosphorylase (hTP) and plays a key role in maintaining the process of DNA replication and repair.
Kali Heale, Alisaraie, Laleh, de Barros, Andre Luis Branco, Laleh Alisaraie, Caroline Manto Chagas, Tozer, Tiffany, Chagas, Caroline Manto, Tiffany Tozer, Andre Luis Branco de Barros, Heale, Kali   +9 more
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Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE [PDF]

, 2008
Bax, BE, Bain, MD, M.M.K. Muqit, Muqit, M. M. K., M. D. Bain, Muqit, MM, Bain, M. D., Moran, N. F., Bax, B. E., N. F. Moran, B. E. Bax, Moran, NF   +11 more
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Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

Case Reports in Anesthesiology, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP).
Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan   +3 more
doaj   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source

Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction. [PDF]

J Am Heart Assoc, 2023
Du L, Yue H, Rorabaugh BR, Li OQY, DeHart AR, Toloza-Alvarez G, Hong L, Denvir J, Thompson E, Li W.   +9 more
europepmc   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Series of Bis-1,2,4-Triazoles as Thymidine Phosphorylase Inhibitor. [PDF]

Adv Appl Bioinform Chem, 2023
Korol N, Holovko-Kamoshenkova OM, Slivka M, Pallah O, Onysko MY, Kryvovyaz A, Boyko NV, Yaremko OV, Mariychuk R.   +8 more
europepmc   +1 more source

Effect of tipiracil hydrochloride, thymidine phosphorylase inhibitor, on the ischemia/reperfusion injury of brain tissue in rats

Scientific Reports
Thymidine phosphorylase (TP) expression is increased in neurons under ischemia/reperfusion (I/R) conditions. Our aim was to evaluate the effect of tipiracil hydrochloride (TPI), a selective TP inhibitor, on rat brain tissue subjected to I/R.
Małgorzata Trocha, Tomasz Piasecki, Paulina Nowotarska, Tomasz Sozański, Anna Merwid-Ląd, Beata Nowak, Marcin Nowak, Rafał Ciaputa, Grzegorz Mazur, Adam Szeląg, Damian Gajecki, Adrian Doroszko   +11 more
doaj   +1 more source

Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase. [PDF]

J Biol Chem, 2023
Harada N, Nagasaki H, Yamamoto H, Matsubara K, Suzuki T, Gomori A, Yokogawa T, Matsuo K, Miyadera K.   +8 more
europepmc   +1 more source

Transition state analysis of thymidine phosphorylase from E. coli. [PDF]

, 2001
Thymidine phosphorylase (E.C. 2.4.2.4) (TP) is an enzyme involved in the reversible conversion of thymidine, deoxyuridine, and their analogs to their respective bases and 2-alpha-D-deoxyribose-1-phosphate. This enzyme is identical to an angiogenic factor,
Rezaei, Mansoureh
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