Results 111 to 120 of about 102,224 (277)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]

, 2014
<b>Background:</b>  Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC ...
Atrih, A., Barton, G., Bray, S. E., Fleming, S., Huang, J. T.-J., Lamont, D. J., Mudaliar, M. A. V., Nabi, G., Zakikhani, P.   +8 more
core   +4 more sources

Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 7, Page 1324-1335, July 2025.
Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri, Tom Macleod, Isabel Hyde, Gregor Jan Ojak, Caroline Mann, Daniela Kramer, Martin Stacey, Miriam Wittmann   +7 more
wiley   +1 more source

Efficacy of adeno-associated virus gene therapy in a MNGIE murine model enhanced by chronic exposure to nucleosides

EBioMedicine, 2020
Background: Preclinical studies have shown that gene therapy is a feasible approach to treat mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Ferran Vila-Julià, Raquel Cabrera-Pérez, Yolanda Cámara, Miguel Molina-Berenguer, Silvia Lope-Piedrafita, Michio Hirano, Federico Mingozzi, Javier Torres-Torronteras, Ramon Martí   +8 more
doaj   +1 more source

Evaluating the Potential of COL8A1 as a Therapeutic Target for Chemoresistance, Disease Progression, and a Prognostic Marker in Gastric Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT This study aimed to identify key genes associated with post‐chemotherapy recurrence in gastric cancer patients. Gene expression data from multiple cohorts were analysed to determine differentially expressed genes between recurrent and non‐recurrent cases. A prognostic risk model incorporating COL8A1, HSPB7 and SLIT2 was developed and validated
Chao Xu, MuZhen He, HongYuan Chen, LiangJie Chi, XiangYu Wang, ShuYuan Li, QingShui Wang, Yao Lin, FangQin Xue   +8 more
wiley   +1 more source

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment. [PDF]

, 2017
Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic ...
Beckman, Robert A., Boca, Simina M., Brody, Jonathan R., Madhavan, Subha, Marshall, John L., Pishvaian, Michael J., Rao, Shruti, Riazi, Shahla, Yabar, Cinthya S.   +8 more
core   +1 more source

Enhancement of DNA synthesis of mouse myelogenous cells by cyclic adenosine 3',5'-monophosphate (cAMP) [PDF]

, 1974
To observe the possible role of cAMP on the DNA synthesis during specialization-division of myelogenous precursor cells, the authors observed the DNA and RNA synthesis of the cells by in vitro autoradiography.
Awai, Michiyasu, Naito, Mitsuko, Okada, Shigeru, Okamoto, Atsuko, Seno, Satimaru   +4 more
core   +1 more source

Thymidine Phosphorylase (TP) Activation: Convenience Through Innovation

The Oncologist, 2001
The management of patients with metastatic colorectal cancer most commonly involves treatment with 5-fluorouracil (5-FU), administered with or without leucovorin (LV) as an i.v. bolus or protracted infusion. Protracted infusion schedules have demonstrated superior efficacy compared with bolus regimens [1], but are associated with greater inconvenience ...
E, Van Cutsem, D, Cunningham, P M, Hoff, J, Maroun   +3 more
openaire   +2 more sources

Folate‐Associated Gene Expression in Primary Tumors Is Associated With Tumor Response and Progression‐Free Survival of Patients With Metastatic Colorectal Cancer Undergoing 5‐FU/Leucovorin‐Based Combination Chemotherapy

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background 5‐Fluorouracil (5‐FU) and the Folate Leucovorin (LV) form the chemotherapy backbone for metastatic colorectal cancer (mCRC). Tumoral expression of specific folate‐associated genes is associated with the risk of recurrence in stage III CRC following adjuvant 5‐FU/LV (FLV)‐based combination chemotherapy according to the Nordic bolus ...
Elisabeth Odin, Göran Carlsson, Pushpa Saksena, Anders Edsjö, Alessandro Di Cara, Roger Tell, Bengt Gustavsson, Yvonne Wettergren   +7 more
wiley   +1 more source

Adjuvant Chemotherapy May be Waived for Breast Cancer Nonresponders to Neoadjuvant Chemotherapy: A Population‐Based Large Cohort Study

Thoracic Cancer, Volume 16, Issue 9, May 2025.
Adjuvant chemotherapy (AC) showed limited benefit in breast cancer patients who did not respond to neoadjuvant chemotherapy (NAC). Overall survival was similar between those who received AC and those who did not. Multivariate and subgroup analyses confirmed no clear advantage of AC.
Lixi Li, Di Zhang, Shuning Liu, Cheng Zeng, Yalong Qi, Fei Ma   +5 more
wiley   +1 more source

Liver as a source for thymidine phosphorylase replacement in mitochondrial neurogastrointestinal encephalomyopathy.

PLoS ONE, 2014
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive mitochondrial disease associated with mutations in the nuclear TYMP gene.
Elisa Boschetti, Roberto D'Alessandro, Francesca Bianco, Valerio Carelli, Giovanna Cenacchi, Antonio D Pinna, Massimo Del Gaudio, Rita Rinaldi, Vincenzo Stanghellini, Loris Pironi, Kerry Rhoden, Vitaliano Tugnoli, Carlo Casali, Roberto De Giorgio   +13 more
doaj   +1 more source