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Thymidine Phosphorylase: The Unforeseen Driver in Colorectal Cancer Treatment?
Future Oncology, 20185-Fluorouracil- and leucovorin-based chemotherapy regimens are the backbone of colorectal cancer treatment. The addition of oxaliplatin, irinotecan and monoclonal antibodies to this backbone has largely improved clinical outcomes, but has also led to new questions, with conflicting data frequently reported in studies.
Tampellini, Marco +3 more
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Thymidine Phosphorylase: A Two-Face Janus in Anticancer Chemotherapy
Current Cancer Drug Targets, 2001Several cytokines and growth factors modulate angiogenesis through a fine tuned paracrine or autocrine mode of action. Among them is plateled-derived endothelial cell growth factor (PD-ECGF), which is highly is expressed in tumors, and is angiogenic by stimulation of endothelial cell migration.
Focher F, Spadari S
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The significance of thymidine phosphorylase expression in colorectal cancer.
Oncology Reports, 2001We measured thymidine phosphorylase activity in colorectal cancer tissue and conducted immunostaining to investigate enzyme expression in the tumor tissue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzyme activity and staining ratios of cancer cells and ...
Takashi Murohashi +11 more
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Thymidine Phosphorylase in Angiogenesis and Drug Resistance
2002TP not only plays a role in sensitivity and resistance to anticancer drugs, but also has a clear angiogenic activity, resulting from its enzymatic activity. TP levels in tumors may be prognostic, but also guide the clinician towards effective therapies.
Michiel de Bruin +6 more
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Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1974
The enzymes thymidine phosphorylase, nucleoside deoxyribosyltransferase and thymidine kinase were searched for in species of Neisseria. Activities corresponding to these enzymes could not be found in the species examined.
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The enzymes thymidine phosphorylase, nucleoside deoxyribosyltransferase and thymidine kinase were searched for in species of Neisseria. Activities corresponding to these enzymes could not be found in the species examined.
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Limited thymidine uptake in Escherichia coli due to an inducible thymidine phosphorylase
Biochimica et Biophysica Acta, 1961Jonathan Rosner +2 more
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Biosynthesis of 3-deoxyribosylxanthine using thymidine phosphorylase
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964Morris Zimmerman, Dolph Hatfield
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