Results 211 to 220 of about 124,338 (379)

HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue 14, 30 July 2025.
ABSTRACT Rationale Edaravone (EDA) is a radical scavenger and an antioxidant drug approved to treat amyotrophic lateral sclerosis and used as a research tool to explore treatment of neurodegenerative diseases and cancers. It is also a reactive agent, known as PMP (1‐phenyl‐3‐methyl‐5‐pyrazolone), used for the analysis of polysaccharides composition ...
Romain Regnault   +5 more
wiley   +1 more source

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister   +4 more
wiley   +1 more source

Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: Sex‐specificity and intergenerational stability

open access: yesMolecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Captive rearing in salmon hatcheries can have considerable impacts on both fish phenotype and fitness within a single generation, even in the absence of genetic change. Evidence for hatchery‐induced changes in DNA methylation is becoming abundant, though questions remain on the sex‐specificity of these effects, their persistence until spawning
Clare J. Venney   +6 more
wiley   +1 more source

Thymine as potential biomarker to predict 5-FU systemic exposure in patients with gastro-intestinal cancer: a prospective pharmacokinetic study (FUUT-trial). [PDF]

open access: yesCancer Chemother Pharmacol
Hanrath MA   +12 more
europepmc   +1 more source

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