Results 1 to 10 of about 16,097 (238)
UVA generates pyrimidine dimers in DNA directly. [PDF]
Biophys J, 2009 There is increasing evidence that UVA radiation, which makes up approximately 95% of the solar UV light reaching the Earth's surface and is also commonly used for cosmetic purposes, is genotoxic. However, in contrast to UVC and UVB, the mechanisms by which UVA produces various DNA lesions are still unclear.
Jiang Y +7 more
europepmc +6 more sources
Formation of Cyclobutane Pyrimidine Dimers after UVA Exposure (Dark-CPDs) Is Inhibited by an Hydrophilic Extract of Polypodium leucotomos [PDF]
Antioxidants, 2021 Exposure to sun and especially to ultraviolet radiation (UVR) exerts well known detrimental effects on skin which are implicated in malignancy. UVR induces production of cyclobutane pyrimidine dimers (CPDs), immediately during exposure and even hours ...
Mikel Portillo-Esnaola +6 more
doaj +2 more sources
Taq DNA polymerase blockage at pyrimidine dimers [PDF]
Nucleic Acids Research, 1996 Nucleic Acids Research, 24 (8)
Ralf Erik Wellinger, Fritz Thoma
exaly +5 more sources
The mechanochemical activation of a pyrimidine dimer. [PDF]
Chem SciThe mechanochemical activation of a cyclobutane-based mechanophore formed by pyrimidine photodimerization, revealing different reactivities of the individual isomers.
Gao X +9 more
europepmc +2 more sources
The compost metagenome as a source of T4 bacteriophage pyrimidine dimer glycosylase homologues [PDF]
E3S Web of Conferences, 2021 Compost is a promising source of thermotolerant enzymes for their application in biotechnology. Homologues of bacteriophage T4 DNA glycosylase can find their application in pharmaceuticals and perfumery.
Karmanova Alexandra N. +2 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2021 UV irradiation induces pyrimidine dimers that block polymerases and disrupt the replisome.
Chettar A Hoff +5 more
doaj +1 more source
Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p. [PDF]
PLoS Genetics, 2015 DNA lesions caused by UV radiation are highly recombinogenic. In wild-type cells, the recombinogenic effect of UV partially reflects the processing of UV-induced pyrimidine dimers into DNA gaps or breaks by the enzymes of the nucleotide excision repair ...
Yi Yin, Thomas D Petes
doaj +1 more source
Perspectives on Cyclobutane Pyrimidine Dimers—Rise of the Dark Dimers† [PDF]
Photochemistry and Photobiology, 2021 ABSTRACTSome early reports demonstrate that levels of cyclobutane pyrimidine dimers (CPD) may increase after UVR exposure had ended, although these observations were treated as artifacts. More recently, it has been shown unequivocally that CPD formation does occur post‐irradiation, with maximal levels occurring after about 2–3 h.
Karl P. Lawrence +4 more
openaire +3 more sources
7-Chloro-3-(4-methylbenzenesulfonyl)pyrrolo[1,2-c]pyrimidine
IUCrData, 2020 In the title compound, C14H11ClN2O2S, the dihedral angle between the pyrrolo[1,2-c]pyrimidine ring system (r.m.s. deviation = 0.008 Å) and the benzene ring is 80.2 (9)°.
Easha Narayan +4 more
doaj +1 more source
Acta Crystallographica Section E, 2012 In the title pyrimidine derivative, C4H4ClN3, the 2-chloro and 4-amino substituents almost lie in the mean plane of the pyrimidine ring, with deviations of 0.003 (1) Å for the Cl atom, and 0.020 (1) & ...
Gerard A. van Albada +3 more
doaj +1 more source