Results 211 to 220 of about 106,654 (267)
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2001
More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
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More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
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Conical Intersections in Thymine
The Journal of Physical Chemistry A, 2006The mechanisms which are responsible for the radiationless deactivation of the npi* and pipi* excited singlet states of thymine have been investigated with multireference ab initio methods (the complete-active-space self-consistent-field (CASSCF) method and second-order perturbation theory with respect to the CASSCF reference (CASPT2)) as well as with ...
Serhiy, Perun +2 more
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Photochemistry of thymine dimers
Journal of Molecular Biology, 1962The extinction coefficient and the quantum yield of photodissociation of a thymine dimer obtained by irradiating thymine in frozen solution have been measured for the range 225 to 289 mμ. The dinucleotides di(thymidine-5′-phosphate) (pTpT), cyclic dithymidylic acid Download : Download full-size image and thymidylyl-(5′−3′)-thymidine ...
H E, JOHNS, S A, RAPAPORT, M, DELBRUECK
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Context-Dependent Photodimerization in Isolated Thymine−Thymine Steps in DNA
Journal of the American Chemical Society, 2008The effect of 280 nm irradiation on a family of synthetic DNA hairpins possessing an alkane linker connecting a six-base pair stem having a single T-T step located at different positions within the hairpin has been investigated. A single adduct assigned to the product of 2+2 dimerization is obtained except in the case of a T-T step located adjacent to ...
Mahesh, Hariharan, Frederick D, Lewis
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Photochemistry and Photobiology, 1969
Abstract— The photochemical and chemical properties of the four dimers of thymine have been studied. The extinction coefficients, reversal cross‐sections and quantum yields for reversal are presented as a function of wavelength in the range 200–289 nm.
M A, Herbert +3 more
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Abstract— The photochemical and chemical properties of the four dimers of thymine have been studied. The extinction coefficients, reversal cross‐sections and quantum yields for reversal are presented as a function of wavelength in the range 200–289 nm.
M A, Herbert +3 more
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Electronic Structure of Thymine
The Journal of Chemical Physics, 1970The electronic structures of the ground and low-lying excited states of thymine and the anions 1-HT− and 3-HT−, derived by removing a proton from nitrogen atom N3 and N1, respectively, have been described by all-electron all-integral LCAO–SCF calculations using Gaussian basis functions.
L C, Snyder, R G, Shulman, D B, Neumann
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PHOTOSENSITIZED DIMERIZATION OF THYMINE
Photochemistry and Photobiology, 1970Abstract— In contrast with previous reports from other laboratories, four isomeric dimers were isolated from the photochemical reaction of thymine sensitized by either acetone or propiophenone. Product analyses, made by use of nuclear magnetic resonance spectroscopy, showed that the distribution of dimers is dependent on the character of the solvent ...
B H, Jennings +2 more
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DNA Repair, 2008
Fifty years ago thymine dimer was discovered in the Biochemical and Biophysical Laboratory of Delft Technological University, The Netherlands, by one of the authors of this review (Beukers) as the first environmentally induced DNA lesion. It is one of the photoproducts formed between adjacent pyrimidine bases in DNA by UV irradiation, currently known ...
Beukers, R (Rudolf) +2 more
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Fifty years ago thymine dimer was discovered in the Biochemical and Biophysical Laboratory of Delft Technological University, The Netherlands, by one of the authors of this review (Beukers) as the first environmentally induced DNA lesion. It is one of the photoproducts formed between adjacent pyrimidine bases in DNA by UV irradiation, currently known ...
Beukers, R (Rudolf) +2 more
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STRUCTURE OF A THYMINE‐THYMINE ADDUCT FORMED BY MENADIONE PHOTOSENSITIZATION
Photochemistry and Photobiology, 1993Abstract— The structure of one of the dithymine adducts formed by near‐UV photosensitization of aqueous oxygenated thymine in the presence of 2‐methyl‐ 1, 4‐naphthoquinone is reported. The compound, 6′β‐hydroxy‐5′β‐1 ‐ [5‐methylpyrimidinyl‐ 2,4‐dione]‐5′‐6′‐dihydrothymine has one thymine ring (ring I) linked through the 1‐nitrogen atom to the C5′ atom ...
H, Katz, W, Stallings, J P, Glusker
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Adhesive Materials Utilizing a Thymine–Adenine Interaction and Thymine Photodimerization
ACS Macro Letters, 2015A cross-linking reagent having two adenine units was mixed with polymers bearing thymine units to form adhesive materials utilizing both intermolecular hydrogen bonding and in situ formation of covalent bonds. In the case of 58 mol % of adenine units relative to thymine units, formation of intermolecular hydrogen bonds because of a thymine-adenine ...
Nobuhiro, Ishikawa +2 more
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