Results 241 to 250 of about 74,896 (329)

Performance of Two Custom Probe Kits for In‐Solution Enrichment of Ancient Avian DNA

Molecular Ecology Resources, Volume 26, Issue 1, January 2026.
ABSTRACT Ancient DNA (aDNA) analysis remains challenging due to low endogenous DNA content of degraded samples. Hybridisation‐based in‐solution enrichment has emerged as an effective tool for targeting genomic regions, enhancing endogenous DNA yield while minimising overall sequencing effort.
Chyi Yin Gwee, Laura Tassoni, Zlatozar Boev, Teresa Tomek, Zbigniew M. Bochenski, Sahra Talamo, Jochen B. W. Wolf   +6 more
wiley   +1 more source

Association of Galanin and Its Receptor Gene Polymorphism with Opioid Dependence: Preliminary Findings from India. [PDF]

Indian J Psychol Med
Naz I, Singh S, Ramawat RB, Kumar R, Quraishi R, Deep R, Ambekar A.   +6 more
europepmc   +1 more source

Myeloid‐Derived CD38 Mediates Age‐Related Endometrial Aging Through NAD+ Depletion

Aging Cell, Volume 25, Issue 1, January 2026.
An increased population of CD38+ macrophages, accompanied by a marked decline in stromal cell NAD+ levels, serves as key hallmarks of endometrial aging in aged mice. Pharmacological and genetic interventions revealed that macrophage‐derived CD38 is a principal driver of uterine NAD+ depletion, thereby accelerating stromal cell senescence and impairing ...
Lun Hua, Luting Liu, Dengfeng Gao, Lulu Ma, Xianyang Jin, Liuyong Lu, Shangbo Tian, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Long Jin, Yong Zhuo, Mingzhou Li, De Wu   +16 more
wiley   +1 more source

Developing glycosylase-based T-to-G and C-to-K base editors in rice. [PDF]

Plant Biotechnol J
Kuang Y, Wu X, Liu M, Yan F, Ma D, Zhou X, Zhou H, Ren B.   +7 more
europepmc   +1 more source

Targeting Wnt/β‐Catenin Pathway by DNA Alkylating Pyrrole‐Imidazole Polyamide in Colon Cancer

Cancer Science, Volume 117, Issue 1, Page 203-215, January 2026.
Wnt/β‐catenin pathway is aberrantly activated in various cancers. We have synthesized a novel DNA alkylating PI polyamide (WNT‐Chb) to target the consensus TCF/LEF‐responsible element. WNT‐Chb downregulated the Wnt‐target genes by inhibiting the recruitment of the β‐catenin/TCF transcription complex and reduced tumor growth in a mouse xenograft tumor ...
Osamu Shimozato, Natsue Akao, Yoko Yanagisawa, Yusuke Mori, Xudong Zhang, Yuki Kida, Rie Igarashi, Takayoshi Watanabe, Toshinori Ozaki, Atsushi Takatori   +9 more
wiley   +1 more source

Development of Synthetic Routes to 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine. [PDF]

Chemistry
Kumagai R, Yamada R, Yamaguchi T, Obika S.   +3 more
europepmc   +1 more source

Pre‐Therapeutic UGT1A1 Genotyping in Breast Cancer Patients Receiving Sacituzumab Govitecan to Improve Safety: A Meta‐Analysis and Recommendation

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Pre‐therapeutic UGT1A1 genotyping is increasingly performed in patients receiving irinotecan, as its active metabolite SN‐38 is primarily cleared through UGT1A1‐mediated glucuronidation. Patients with the UGT1A1*28/*28 genotype exhibit reduced UGT1A1 activity, leading to increased SN‐38 exposure and a higher risk of adverse events such as ...
Tessa Goedhart, Henk‐Jan Guchelaar
wiley   +1 more source

Disrupting Viral Persistence: CRISPR/Cas9‐Based Strategies for Hepatitis B and C Treatment, and Challenges

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Hepatitis B and C viruses (HBV and HCV) remain among the leading causes of liver disease worldwide. Current antiviral drugs, such as nucleotide analogues (NAs), can reduce the replication of new HBV and HCV infections but cannot completely eliminate chronic infections.
Meng‐Fan Li, Akmal Zubair, Safa Wdidi, Shan He   +3 more
wiley   +1 more source

Thymine as potential biomarker to predict 5-FU systemic exposure in patients with gastro-intestinal cancer: a prospective pharmacokinetic study (FUUT-trial). [PDF]

Cancer Chemother Pharmacol
Hanrath MA, Banken E, van den Wildenberg SAH, van de Kerkhof D, Moes DJAR, Boisdron-Celle M, van den Bosch BJC, Bax R, Bet PM, Maring JG, Creemers GM, van Hellemond IEG, Deenen MJ.   +12 more
europepmc   +1 more source