Results 91 to 100 of about 316,970 (234)

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, EarlyView.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Identification of Potential Key Genes for the Comorbidity of Myasthenia Gravis With Thymoma by Integrated Bioinformatics Analysis and Machine Learning

Bioinformatics and Biology Insights
Background: Thymoma is a key risk factor for myasthenia gravis (MG). The purpose of our study was to investigate the potential key genes responsible for MG patients with thymoma.
Hui Liu, Geyu Liu, Rongjing Guo, Shuang Li, Ting Chang   +4 more
doaj   +1 more source

Thymomatous myasthenia gravis [PDF]

, 2010
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder targeting skeletal muscle acetylcholine receptor. Thymoma is associated with MG in some patients, the majority of whom present with symptoms of MG before detection of underlying thymoma.
Chan, KH, Cheung, RTF, Chu, ACY, Ho, PWL, Ho, SL, Liu, HHW, Mak, W, Pang, SYY, Tsang, JWH, Tse, MMY   +9 more
core  

Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? [PDF]

, 2012
Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism.
Boyd, Jonathan D, Juskevicius, Ridas
core   +2 more sources

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source

A pregnant woman with thymoma-associated pure red cell aplasia

BMC Pregnancy and Childbirth, 2022
Background Pure red cell aplasia (PRCA) is a hematological disorder characterized by anemia with severe reticulocytopenia caused by a marked reduction in erythroid precursors in the bone marrow.
Megumi Shibata, Kayoko Kaneko, Nagayoshi Umehara, Hitoshi Matsui, Toshinao Kawai, Hisaya Nakadate, Atsuko Murashimia, Haruhiko Sago   +7 more
doaj   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

The Immunological considerations in patients with Thymoma : A case report with lessons beyond resection [PDF]

, 2023
M. Szpytma, Yan‐Ling Yang, Gareth Crouch   +2 more
openalex   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Surgical therapy of thymic tumours with pleural involvement: an ESTS Thymic Working Group Project [PDF]

, 2017
OBJECTIVES Surgery for thymic epithelial tumours (TETs) with pleural involvement is infrequently performed. Thus, the value of surgical therapy for primary or recurrent TETs with pleural involvement is not sufficiently defined yet.
Bille, Andrea, Brioude, Geoffrey, de Antonio, David Gómez, de Perrot, Marc, Fabre, Dominique, Fadel, Elie, Guerrera, Francesco, Janik, Stefan, Jungraithmayr, Wolfgang, Keshavjee, Shaf, Klepetko, Walter, Lang-Lazdunski, Loic, Liberman, Moishe, Moser, Bernhard, Novoa, Nuria, Ruffini, Enrico, Scarci, Marco, Thomas, Pascal, Van Raemdonck, Dirk, Viskens, Sophie, Weder, Walter   +20 more
core   +1 more source