Results 121 to 130 of about 33,800 (232)

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

open access: yesEnvironmental Toxicology, Volume 41, Issue 9, Page 670-681, September 2026.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min   +3 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan   +3 more
wiley   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

open access: yesReviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík   +2 more
wiley   +1 more source

Limited Efficacy of Autologous Mesenchymal Stromal Cell Injections in Immunomodulatory‐Dependent Dogs With Aqueous Deficient Dry Eye Disease

open access: yesVeterinary Ophthalmology, Volume 29, Issue 5, September 2026.
ABSTRACT Objective Aqueous deficient dry eye disease (ADDE) results from a quantitative reduction in aqueous tears. We sought to determine the clinical effect of autologous mesenchymal stromal cell (MSC) injections into the region of the lacrimal gland and the gland of the third eyelid in immunomodulatory‐dependent ADDE‐affected dogs. Methods Dogs (n = 
Brian C. Leonard   +9 more
wiley   +1 more source

Chitosan‐induced modulation of secondary metabolism and stress tolerance in Salvia rosmarinus under combined drought and heat stress

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 10, Page 5989-6001, 15 August 2026.
Abstract BACKGROUND Abiotic stresses, particularly drought and elevated temperatures, negatively affect plant physiological and metabolic processes. This study investigated the effects of drought, heat, and combined stress on Salvia rosmarinus (rosemary), and evaluated foliar‐applied chitosan as a biostimulant.
Inês Mansinhos   +6 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

open access: yes
Transfusion, EarlyView.
Thane Kubik   +2 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

open access: yesAdvanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen   +6 more
wiley   +1 more source

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