Results 131 to 140 of about 33,800 (232)

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Effects of Timing of Microbial Exposure on Microbiome Assembly and Amphibian Immune Development

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We used a novel amphibian gnotobiotic system to investigate how disruptions to the microbiome during critical developmental periods influence microbial assembly and the development of immunity. We found that antimicrobial treatments of embryos and subsequent introduction to microbes at different developmental stages altered microbiome assembly ...
Abigail J. Miller, Myung Chul Jo, Cassandra K. Hui, Juli Petereit, Douglas C. Woodhams, Jamie Voyles   +5 more
wiley   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Primary hyperparathyroidism due to dual parathyroid adenomas: one orthotopic, one intrathymic in ectopic cervical thymus. [PDF]

JCEM Case Rep
Iglesias M, Lewis J, Janus J, Abate E, Chindris AM.   +4 more
europepmc   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Comment on "The role of thymus preservation in parathyroid gland function and surgical completeness after bilateral central lymph node dissection for papillary thyroid cancer: a randomized controlled study". [PDF]

Int J Surg
Hong S, Chen Y.
europepmc   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.
ABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Ectopic Cervical Thymoma with Myasthenia Gravis and Pure Red Cell Aplasia: A Case Report. [PDF]

Surg Case Rep
Narusawa E, Obayashi K, Obayashi S, Nagashima T, Kawatani N, Yazawa T, Yoshikawa R, Matsumura N, Shirabe K, Nakazawa S.   +9 more
europepmc   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source