Results 151 to 160 of about 33,746 (240)

Immunomodulatory Effects of Wheat Peptides and a Novel Octapeptide (GFNDLGKR) in Immunosuppressed Zebrafish and Mouse Models

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Wheat peptides (WP) exerted immunomodulatory effects in both zebrafish and mouse immunosuppressed models, restoring immune cells, cytokines, organ indices, and SCFAs. A novel octapeptide, GFNDLGKR (GR8), was identified via LC–MS/MS and molecular docking targeting CHRM1.
Fei Shen   +10 more
wiley   +1 more source

Regulatory T cells in primary sjögren disease: regulatory mechanisms and therapeutic prospects. [PDF]

open access: yesFront Immunol
Chengzhi W   +5 more
europepmc   +1 more source

A Review of Extraction, Structural Properties, Biological Activities of Dendrobium chrysotoxum Polysaccharides

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Overview of extraction, biological activities, and application prospects of DCP. (a) Collection, weighing, shearing, and grinding of D. chrysotoxum stems. (b) Aqueous extraction, ultracentrifugation, drying, and filtration to obtain purified DCP. (c) Mechanistic studies and preclinical or retrospective clinical investigations of DCP bioactivities.
Xingshuai Zhang   +4 more
wiley   +1 more source

Toxicological Evaluation of the Roots of Ficus pandurata Hance var. angustifolia Cheng

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Toxicological evaluation of the roots of Ficus pandurata Hance var. angustifolia Cheng for safe utilization. Two‐year‐old RFPH roots were prepared as an aqueous extract powder, with 1 g equivalent to 30 g of raw material. Acute oral toxicity, genotoxicity, teratogenicity, and 90‐day repeated‐dose oral toxicity tests were performed in SD rats and ICR ...
Yamin Chen   +12 more
wiley   +1 more source

Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Efficient and specific delivery of mRNA to target tissues is critical for maximising therapeutic benefits while minimising off‐target effects and systemic toxicity. Systemic administration of mRNA using lipid nanoparticles (LNPs) or extracellular vesicles (EVs) typically leads to predominant accumulation in the liver.
Muhammad Nawaz   +13 more
wiley   +1 more source

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill   +7 more
wiley   +1 more source

Biogenic Silver Nanoparticles in Diabetes: In Vivo Mechanisms, Therapeutic Potential, and Future Perspectives: A Review

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Biogenic silver nanoparticles exhibit antidiabetic potential by improving glycemic control, enhancing insulin sensitivity, and preserving pancreatic β‐cell function. They act through antioxidant and anti‐inflammatory mechanisms, modulating ROS, NF‐κB, and PI3K/Akt pathways, while providing multi‐organ protection, highlighting their promise as ...
Nourhane A. Darwich   +2 more
wiley   +1 more source

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