Results 161 to 170 of about 262,172 (291)

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

Aging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies. [PDF]

Aging Cell
Thymic involution, the age‐related replacement of thymic soft tissue by fat, has been linked to immunosenescence and chronic inflammation. Whether HIV infection affects thymic involution remains unclear. We found that people with HIV on long‐term antiretroviral therapy had more thymic tissue than controls, indicating less thymic involution. More thymic
Vanbellinghen MC, Boyd A, Johansen AO, Suarez-Zdunek MA, Knudsen AD, Kristensen TS, Kühl JT, Sigvardsen PE, Pham MHC, Larsen AF, Kofoed KF, Nordestgaard BG, Afzal S, Kootstra N, Nielsen SD, Reiss P.   +15 more
europepmc   +2 more sources

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Characterizing bone metastases and skeletal‐related events in patients with well‐differentiated neuroendocrine neoplasms utilizing 68Gallium‐DOTATATE positron emission tomography

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Tumors of neuroendocrine origin are a heterogenous group of related neoplasms which can arise from anywhere in the body. Neuroendocrine neoplasms (NENs) are categorized by site of origin, differentiation status and grade (Ki‐67 expression and/or mitotic rate), with significant prognostic variability accordingly. Historically, the prevalence of
Tucker W. Coston, Himil J. Mahadevia, Marie M. Plante, Alex Hochwald, Joseph M. Accurso, Akash Sharma, Geoffrey B. Johnson, Jonathan B. Ashman, A. Tuba Kendi, Mohamad Bassam Sonbol, Patrick W. McGarrah, Timothy J. Hobday, Thorvardur R. Halfdanarson, Jason S. Starr   +13 more
wiley   +1 more source

ASPECTS OF THE THYMUS (THYMUS) IN CHILDREN

A huge mystery of biology, medicine (primarily immunology) and in particular pediatrics is the thymus gland (thymus). And this despite the fact that he attracted the closest attention of researchers for 4 centuries or more.
Sh. O., Korzhavov, G. B., Kuvandikov, N. A., Bakhodirova   +2 more
core  

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, Volume 49, Issue 11, Page 8437-8453, November 2026.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, Volume 13, Issue 55, 5 October 2026.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, Volume 13, Issue 59, 23 October 2026.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source