Results 181 to 190 of about 262,172 (291)

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

open access: yesCurrent Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark   +5 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu   +7 more
wiley   +1 more source

A Multimodal Morphological and Immunohistochemical Analysis of the Human Thymus-Parathyroid Relationship. [PDF]

open access: yesInt J Mol Sci
Comanescu MP   +9 more
europepmc   +1 more source

Maternal and Postnatal Effects of Poly I:C‐Induced Intrauterine Inflammation and Rytvela, a Non‐Competitive IL‐1R Antagonist, in the Pregnant Spiny Mouse

open access: yesDevelopmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Maternal infection‐induced inflammation during pregnancy is associated with adverse neurodevelopment. Rytvela, an allosteric IL‐1 receptor antagonist, reduces IL‐1β‐mediated pathology in fetal rodents and sheep. However, its effects on TLR3‐mediated inflammation and subsequent offspring growth and behavior remain unclear. Using precocial spiny
Nhi T. Tran   +7 more
wiley   +1 more source

Intrathyroidal thymic tissue: a pediatric case series from a secondary care center. [PDF]

open access: yesAnn Pediatr Endocrinol Metab
Pereira RS   +5 more
europepmc   +1 more source

Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis

open access: yesEuropean Journal of Immunology, Volume 56, Issue 10, October 2026.
This study is focussed on the role of cAMP‐dependent transcriptional repressor ICER in regulatory T cell function. Using a conditional knockout model, Treg development, suppressive function, stability, and metabolic phenotype were examined to gain further understanding of the role of cAMP‐dependent signalling in regulatory T cells.
Aleksandra Lopez Krol   +12 more
wiley   +1 more source

Discovery of Avian TCRVβ2+ T Cells Recognizing the Endogenous Ganglioside via a chCD1.1‐Dependent Pathway

open access: yesEuropean Journal of Immunology, Volume 56, Issue 10, October 2026.
We present the first report of chicken lipid‐reactive, NKT‐like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen‐presenting cells. This activation induces a rapid cytokine response from avian lipid‐reactive T cells, offering a universal target for lipid‐adjuvanted poultry vaccines.
Nitin Kamble   +2 more
wiley   +1 more source

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