Results 211 to 220 of about 61,133 (325)

Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions

open access: yesAllergy, Volume 81, Issue 2, Page 326-344, February 2026.
ABSTRACT Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment ...
Marjolein S. de Bruin‐Weller   +9 more
wiley   +1 more source

First‐in‐Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin‐S Inhibitor, in Healthy Adult Subjects

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT ASP1617 is a novel, highly selective inhibitor of cathepsin‐S, an important protease for antigen peptide loading onto major histocompatibility complex class II molecules. Preclinically, ASP1617 prevented progression of lupus‐like glomerulonephritis in an NZB/W F1 mouse model of systemic lupus erythematosus.
Tomoki Kojima   +9 more
wiley   +1 more source

Mechanical Insights into the Distinct Effects of Ovariectomy Versus Adrenalectomy on Age-Related Thymic Atrophy in Female Mice. [PDF]

open access: yesInt J Mol Sci
Chen J   +11 more
europepmc   +1 more source

In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children [PDF]

open access: yes, 1994
Bustos, M.   +6 more
core   +1 more source

Pathologic assessment of resected stage III non‐small cell lung cancer after neoadjuvant chemotherapy: identification of additional prognostic factors

open access: yesHistopathology, Volume 88, Issue 3, Page 710-728, February 2026.
Multiple pathological variables are associated with prognosis in resected NSCLC at stage III undergoing neoadjuvant treatment, namely vascular, perineural and pleural infiltration, proliferation index, pathological response, fibrosis and presence of lymphocytes in the tumour bed.
Francesca Lunardi   +11 more
wiley   +1 more source

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