Results 151 to 160 of about 8,157,530 (188)

Radioiodine and thyroid-associated ophthalmopathy

open access: yesOrbit, 1996
Particular attention has recently been paid to the relationship between radioiodine administration and the course of thyroid-associated ophthalmopathy (TAO). Conflicting results have been reported in the literature, and radioiodine therapy has been associated either with aggravation, improvement, or no relevant changes of eye disease.
Fausto Bogazzi   +2 more
exaly   +3 more sources

Rituximab for thyroid-associated ophthalmopathy

Cochrane Database of Systematic Reviews, 2013
Thyroid associated ophthalmopathy (TAO) is the most frequent extrathyroidal manifestation of Graves' disease, affecting up to 50% of patients, and has a great impact on quality of life. Rituximab is a human/murine chimeric monoclonal antibody that targets CD20, a transmembrane protein expressed on the surface of pre-B and mature B lymphocytes, but not ...
Neda, Minakaran, Daniel G, Ezra
openaire   +4 more sources

Infliximab: A Novel Treatment for Sight-Threatening Thyroid Associated Ophthalmopathy

open access: yesOrbit, 2005
We describe a patient with sight threatening thyroid associated ophthalmopathy (TAO) who was successfully treated with infliximab, an anti-tumour necrosis factor (TNF)-a ...
Philip Murray
exaly   +2 more sources

Pathogenesis of thyroid-associated ophthalmopathy

Trends in Endocrinology & Metabolism, 1993
Thyroid-associated ophthalmopathy is a complex disease whose pathogenesis is thought to be autoimmune. Evidence has accumulated to implicate lymphocytes, antibodies, and cytokines targeting the orbital tissues whose structural and functional characteristics are unique.
P, Perros, P, Kendall-Taylor
openaire   +2 more sources

The pathophysiology of thyroid-associated ophthalmopathy

Ophthalmology Clinics of North America, 2002
TAO is an inflammatory disease of the orbital tissues. The effects of inflammation, mediated through cytokine release, include proliferation of fibroblasts, increased deposition of extracellular matrix, and adipocyte differentiation and proliferation. As a result, edema, enlargement of the extraocular muscles, and increased volume of the orbital soft ...
Mark P, Hatton, Peter A D, Rubin
openaire   +2 more sources

2021 update on thyroid-associated ophthalmopathy

Journal of Endocrinological Investigation, 2021
Our understanding of thyroid-associated ophthalmopathy (TAO, A.K.A Graves' orbitopathy, thyroid eye disease) has advanced substantially, since one of us (TJS) wrote the 2010 update on TAO, appearing in this journal.PubMed was searched for relevant articles.Recent insights have resulted from important studies conducted by many different laboratory ...
E. J. Neag, T. J. Smith
openaire   +2 more sources

The pathogenesis of thyroid-associated ophthalmopathy

Journal of Endocrinology, 1989
Introduction Thyroid-associated ophthalmopathy (TAO) is closely related to Graves' hyperthyroidism and is characterized by periorbital oedema, conjunctival injection, exophthalmos, extraocular muscle dysfunction and, in its severe form, exposure keratitis and optic nerve compression. The extraocular muscles (EOM)
P, Perros, P, Kendall-Taylor
openaire   +2 more sources

Octreoscan in Thyroid-Associated Ophthalmopathy

Thyroid, 2002
Until recently, there was no imaging technique available that could be considered as a reliable measure of inflammation in thyroid-associated opthalmopathy (TAO). Pentetreotide (a synthetic derivative of somatostatin) labeled with 111In has been used to visualize somatostatin receptors in endocrine-related tumours in vivo.
openaire   +2 more sources

Natural history of thyroid associated ophthalmopathy

Clinical Endocrinology, 1995
SummaryBACKGROUND The natural history of thyroid associated ophthalmopathy is poorly documented, although It is widely thought that many cases Improve spontaneously with time. This has Important Implications in the management of patients and is also a critical factor when assessing the effects of different treatments.OBJECTIVE To document the natural
P, Perros   +2 more
openaire   +2 more sources

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