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Progress in thyroid-associated ophthalmopathy.
J, Wall, J S, Kennerdell
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Radioiodine and thyroid-associated ophthalmopathy
Particular attention has recently been paid to the relationship between radioiodine administration and the course of thyroid-associated ophthalmopathy (TAO). Conflicting results have been reported in the literature, and radioiodine therapy has been associated either with aggravation, improvement, or no relevant changes of eye disease.
Fausto Bogazzi +2 more
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Rituximab for thyroid-associated ophthalmopathy
Cochrane Database of Systematic Reviews, 2013Thyroid associated ophthalmopathy (TAO) is the most frequent extrathyroidal manifestation of Graves' disease, affecting up to 50% of patients, and has a great impact on quality of life. Rituximab is a human/murine chimeric monoclonal antibody that targets CD20, a transmembrane protein expressed on the surface of pre-B and mature B lymphocytes, but not ...
Neda, Minakaran, Daniel G, Ezra
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Infliximab: A Novel Treatment for Sight-Threatening Thyroid Associated Ophthalmopathy
We describe a patient with sight threatening thyroid associated ophthalmopathy (TAO) who was successfully treated with infliximab, an anti-tumour necrosis factor (TNF)-a ...
Philip Murray
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Pathogenesis of thyroid-associated ophthalmopathy
Trends in Endocrinology & Metabolism, 1993Thyroid-associated ophthalmopathy is a complex disease whose pathogenesis is thought to be autoimmune. Evidence has accumulated to implicate lymphocytes, antibodies, and cytokines targeting the orbital tissues whose structural and functional characteristics are unique.
P, Perros, P, Kendall-Taylor
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The pathophysiology of thyroid-associated ophthalmopathy
Ophthalmology Clinics of North America, 2002TAO is an inflammatory disease of the orbital tissues. The effects of inflammation, mediated through cytokine release, include proliferation of fibroblasts, increased deposition of extracellular matrix, and adipocyte differentiation and proliferation. As a result, edema, enlargement of the extraocular muscles, and increased volume of the orbital soft ...
Mark P, Hatton, Peter A D, Rubin
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2021 update on thyroid-associated ophthalmopathy
Journal of Endocrinological Investigation, 2021Our understanding of thyroid-associated ophthalmopathy (TAO, A.K.A Graves' orbitopathy, thyroid eye disease) has advanced substantially, since one of us (TJS) wrote the 2010 update on TAO, appearing in this journal.PubMed was searched for relevant articles.Recent insights have resulted from important studies conducted by many different laboratory ...
E. J. Neag, T. J. Smith
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The pathogenesis of thyroid-associated ophthalmopathy
Journal of Endocrinology, 1989Introduction Thyroid-associated ophthalmopathy (TAO) is closely related to Graves' hyperthyroidism and is characterized by periorbital oedema, conjunctival injection, exophthalmos, extraocular muscle dysfunction and, in its severe form, exposure keratitis and optic nerve compression. The extraocular muscles (EOM)
P, Perros, P, Kendall-Taylor
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Octreoscan in Thyroid-Associated Ophthalmopathy
Thyroid, 2002Until recently, there was no imaging technique available that could be considered as a reliable measure of inflammation in thyroid-associated opthalmopathy (TAO). Pentetreotide (a synthetic derivative of somatostatin) labeled with 111In has been used to visualize somatostatin receptors in endocrine-related tumours in vivo.
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Natural history of thyroid associated ophthalmopathy
Clinical Endocrinology, 1995SummaryBACKGROUND The natural history of thyroid associated ophthalmopathy is poorly documented, although It is widely thought that many cases Improve spontaneously with time. This has Important Implications in the management of patients and is also a critical factor when assessing the effects of different treatments.OBJECTIVE To document the natural
P, Perros +2 more
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