Results 81 to 90 of about 409,329 (397)

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Scientific Reports, 2015
Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer.
Steffy W. M. Jansen, A. A. Akintola, F. Roelfsema, E. Spoel, C. Cobbaert, B. Ballieux, P. Egri, Zsuzsanna Kvárta-Papp, B. Gereben, C. Fekete, P. Slagboom, J. V. D. Grond, B. Demeneix, H. Pijl, R. Westendorp, D. Heemst   +15 more
semanticscholar   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Patterns of Thyroid Dysfunction among Women with Menstrual Disorder

Advanced Medical Journal
Background and objectives: Thyroid dysfunction can lead to menstrual irregularities and infertility. Thus, this study aimed to assess the frequency and patterns of thyroid dysfunction in patients with menstrual disorders.
Chrakhan Mohemmed Haji Rasul, Taha Othman Mahwy, Zagros Ghaffor Rashid   +2 more
doaj   +1 more source

Analysis of structure-activity and structure-mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging ToxCast library [PDF]

, 2023
Ajaya Kumar Sahoo, Shanmuga Priya Baskaran, Nikhil Chivukula, Kishan Kumar, Areejit Samal   +4 more
openalex   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Evaluation of thyroid function in a sample of newborns through different modes of delivery

Zanco Journal of Medical Sciences, 2019
Background and objective: Congenital hypothyroidism is the most common preventable cause of mental retardation detected during early childhood. Its early diagnosis is crucial for a better outcome.
Sasan L. Hanna, Awat I. Hamadamen, Dlair A.K. Chalabi   +2 more
doaj   +1 more source

BRAF-Activated Long Noncoding RNA Modulates Papillary Thyroid Carcinoma Cell Proliferation through Regulating Thyroid Stimulating Hormone Receptor

Cancer research and treatment : official journal of Korean Cancer Association, 2015
Purpose The importance of long noncoding RNAs (lncRNAs) in tumorigenesis has recently been demonstrated. However, the role of lncRNAs in development of thyroid cancer remains largely unknown. Materials and Methods Using quantitative reverse transcription
Hai-tao Zheng, M. Wang, Li-xin Jiang, Haidi Chu, Jinchen Hu, Jinyao Ning, Baoyuan Li, Dong Wang, Jie Xu   +8 more
semanticscholar   +1 more source

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Assink, Y., Berg, J.H.J. van den, Bergman, A., Brouwer, A., Cenijn, P.H., Koeman, J.H., Meerts, I.A.T.M., Weijers, B.M.   +7 more
core   +4 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source