Results 191 to 200 of about 14,074 (215)
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[Thyroid-stimulating immunoglobulins. The related antigens].
Annales d'endocrinologie, 1982The presence of thyroid stimulating antibodies (TSAb) in patients with Graves' disease is well established. Considerable evidence has accumulated that these are antibodies to thyroid plasma membrane components related to the TSH receptor. The question of whether thyroid stimulation is mediated by a direct interaction with the TSH binding site is still ...
Pinchera A +5 more
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Thyroid-stimulating immunoglobulins indicate the onset of dysthyroid optic neuropathy
Journal of Endocrinological Investigation, 2015Recognition of dysthyroid optic neuropathy (DON) requires sensitive diagnostic tools. Clinical assessment may fail to reliably evaluate the acuteness of DON especially if signs for inflammation are missing. Aim of this cross-sectional study was to assess the relationship between thyroid-stimulating immunoglobulins (TSI) and onset of DON.At a ...
K A, Ponto +6 more
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THE ROLE OF THYROID STIMULATING IMMUNOGLOBULINS OF GRAVES'S DISEASE IN NEONATAL THYROTOXICOSIS
BJOG: An International Journal of Obstetrics & Gynaecology, 1978SummaryGraves's disease is characterized by hyperthyroidism, a diffuse, uniform enlargement of the thyroid gland and marked eye signs. It is now widely believed that the thyroid overactivity of Graves's disease is a result of the presence in the circulation of abnormal thyroid stimulating immunoglobulins (TSIg).
D S, Munro +4 more
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Isoelectric Focusing of Long-Acting Thyroid Stimulator Immunoglobulin G
The Journal of Clinical Endocrinology & Metabolism, 1973Isoelectric focusing of long-acting thyroid stimulator immunoglobulin G [LATS-IgG] was used to determine the distribution of LATS activity among IgGs of various isoelectric points and to determine if isoelectric focusing techniques might yield LATS-IgG of increased biologic activity.
C, Lonergan, D, Babiarz, G, Burke
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Thyroid stimulating immunoglobulin in Graves' disease.
Australian and New Zealand journal of medicine, 1981There is excellent presumptive evidence that an IgG plays an aetiological role in the development of hyperthyroidism in Graves' disease but available methods for detecting thyroid stimulating immunoglobulins (TSI) are still far from satisfactory.
B M, Luttrell, I B, Hales
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Thyroid Stimulating Immunoglobulins in Graves' disease diagnosis
Clinical chemistry and laboratory medicine, 2018Aim Graves' disease is the most common cause of hyperthyroidism. It is autoimmune disorder caused by the presence of thyroid stimulating immunoglobulins (TSI) that bind to the TSH receptor (TSHR) and mimic Thyroid Stimulating Hormone (TSH) stimulation of the thyroid cells resulting in uncontrolled production of thyroid hormones that leads to ...
Fijačko, Mirjana +3 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2013
Background Macrocomplexes can be the cause of elevated serum hormone concentrations and may cause diagnostic confusion. This is well recognized for prolactin and commonly screened for using polyethylene glycol (PEG) precipitation.
Francesca, Mills +4 more
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Background Macrocomplexes can be the cause of elevated serum hormone concentrations and may cause diagnostic confusion. This is well recognized for prolactin and commonly screened for using polyethylene glycol (PEG) precipitation.
Francesca, Mills +4 more
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Thyroid-Stimulating Immunoglobulin Bioassay Using Cultured Human Thyroid Cells*
The Journal of Clinical Endocrinology & Metabolism, 1981Modifications are described in the cultured thyroid cell cAMP assay for TSH which make it suitable for the measurement of thyroid-stimulating immunoglobulins. Comparison was made between this assay and two others measuring cAMP responsiveness in human thyroid tissue, namely the thyroid slice and thyroid plasma membrane adenylate cyclase assays, all ...
W. E. Hinds +4 more
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The distribution of the long-acting thyroid stimulator among γG-immunoglobulins
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1969γG-globulin prepared from long-acting thyroid stimulator (LATS) serum using (NH4)2SO4 precipitation and DEAE-cellulose chromatography sometimes was found to have a lower specific LATS activity than a dilution of the original serum containing a comparable amount of γG-globulin.
B R, Smith, D S, Munro, K J, Dorrington
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Letter: Thyroid-stimulating immunoglobulins.
Lancet (London, England), 1975link_to_subscribed_fulltext
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