Results 71 to 80 of about 518,239 (266)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Theranostic Potentials of Metallic Nanoparticles in Thyroid Diseases: Challenges and Prospects

International Journal of Nanomedicine
Siyu Li,1,* Ying Shi,2,* Xianbin Cheng,1 Mingmei Huangfu,1 Hao Zhang,1 Xiangfu Ding1 1Department of Thyroid Surgery, The Second Hospital of Jilin University, Changchun, 130000, People’s Republic of China; 2Department of Breast Surgery ...
Li S, Shi Y, Cheng X, Huangfu M, Zhang H, Ding X   +5 more
doaj  

Significant role of 1,25-dihydroxyvitamin D on serum calcium levels after total thyroidectomy: a prospective cohort study

Frontiers in Endocrinology
IntroductionAlthough active vitamin D (VD) has been used both preoperatively and postoperatively to prevent hypocalcemia risk in patients undergoing total thyroidectomy, the role of 1,25-dihydroxyvitamin D (1,25(OH)2D) has not been examined.
Hiroyuki Yamashita, Yusuke Mori, Shinya Sato, Hisakazu Shindo, Kouichi Yoshimoto, Seigo Tachibana, Takashi Fukuda, Hiroshi Takahashi   +7 more
doaj   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

Preoperative Circulating Tumor Cells (CTCs) Positivity is Associated with Lymph Node Metastasis in Patients with Unifocal Papillary Thyroid Microcarcinoma (PTMC)

International Journal of General Medicine
Haifeng Zhong, Qingxin Zeng, Yuedong Wang, Jiwei Chen Department of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Jiwei Chen, Department of Thyroid Surgery, Meizhou ...
Zhong H, Zeng Q, Wang Y, Chen J
doaj  

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Surgical Management of Recurrent Plasma Cell Mastitis in a Male Patient: A Case Report

International Medical Case Reports Journal
Ting Yang,1 Haijiao Luo,2 Jing Zhou,1 Zhongxu Duan,1 Jingfeng Jing,1 Han Gao1 1Department of Breast and Thyroid, Women and Children’s Hospital of Chongqing Medical University: Chongqing Health Center for Women and Children, Chongqing, People’s Republic ...
Yang T, Luo H, Zhou J, Duan Z, Jing J, Gao H   +5 more
doaj