Results 181 to 190 of about 3,138,389 (246)
Routine radioactive iodine (RAI) after thyroidectomy in low‐risk differentiated thyroid cancer shows no clear benefit in reducing recurrence or improving survival. These findings support a selective, risk‐based approach, avoiding unnecessary treatment and potential adverse effects.
Maheen Asif +5 more
wiley +1 more source
Health consumer complaints to the New Zealand Health and Disability Commissioner involving sonographers are rare, totalling 15 in the last 31 years and averaging 1.5 cases per year over the last decade. A large proportion of complaints involve an undetected finding, obstetric examination and private setting.
Martin Necas +5 more
wiley +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk
Abstract Objective Develop a preoperative risk classifier for guiding the extent of surgery in differentiated thyroid carcinomas (DTCs) under 4 cm. Study Design In silico study, validation with retrospective cohort. Setting Genomic data repositories, academic tertiary medical center.
Thomas F. Barrett +18 more
wiley +1 more source
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal +5 more
wiley +1 more source
Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang +4 more
wiley +1 more source
ABSTRACT Immune checkpoint inhibitor (ICI)‐driven alterations in the immune system can induce immune‐related adverse events (irAEs). Cutaneous irAEs are notable for being the most common and for their early onset; however, the risk factors underlying their development and severity remain unclear. In this study, we retrospectively analyzed 1224 Japanese
Tomoya Watanabe +4 more
wiley +1 more source
circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang +4 more
wiley +1 more source
Across four independent thyroid cancer cohorts, multi‐omics analysis identifies a reproducible APOC1–LPL–VLDLR lipid‐pathway signature linked to the preoperative diagnostic‐to‐treatment interval, nominating triglyceride‐rich lipoprotein metabolism as a candidate window for monitoring and a potential metabolic axis in papillary thyroid carcinoma ...
Yinfeng Li +4 more
wiley +1 more source

