Results 101 to 110 of about 527,362 (224)

Anaplastic thyroid carcinoma: novel therapeutic targets and strategies [PDF]

, 2008
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies, with a mean survival of only 6 months. Therefore, novel therapeutic approaches are desperately required. - dl1520 is a replication competent adenovirus that, due to lack
Libertini, Silvana
core   +1 more source

Psychological well-being on thyroid hormone replacement [PDF]

Despite 100 years after the discovery of thyroxine, controversy still exists regarding optimal thyroid hormone replacement therapy. Several anecdotal reports suggest that thyroxine alone therapy does not normalise psychological wellbeing.
Saravanan, Ponnusamy
core  

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Parathyroid Double Adenoma Associated with Papillary Carcinoma of Thyroid [PDF]

It has been reported that thyroid disease is common in patients with hyperparathyroidism, and vice versa. Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT).
دادخواه, مینو, ایرانپرور, منوچهر, پورفرضی, فرهاد, رستمی, خلیل   +3 more
core  

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Diagnostic Options in Graves' or Non‐Graves' Thyrotoxicosis: A Review for Clinical Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Distinguishing Graves' disease (GD) from the other causes of thyrotoxicosis is essential for appropriate management. The clinical phenotype of GD has evolved over time and is currently more heterogenous and milder than in the past. Consequently, the differential diagnosis of thyrotoxicosis is often challenging.
Lorenzo Scappaticcio, Pierpaolo Trimboli, Paola Caruso, Chiara Porcellini, Daniela Forestiere, Maria Ida Maiorino, Katherine Esposito, Giuseppe Bellastella   +7 more
wiley   +1 more source

Microarray-Based Avidity Assay for Assessment of Thyroid Autoantibodies

Diagnostics
Background/Objectives: The aim of this study was to evaluate the avidity of thyroid autoantibodies (Abs) in sera of patients with autoimmune thyroid disease (AITD) and thyroid autoantibody carriers without diagnosed AITD.
Elena Savvateeva, Vera Sokolova, Marina Yukina, Nurana Nuralieva, Elena Kulagina, Maxim Donnikov, Lyudmila Kovalenko, Maria Kazakova, Ekaterina Troshina, Dmitry Gryadunov   +9 more
doaj   +1 more source

Reduced Circulating Regulatory T Cells in Autoimmune and Chronic Idiopathic Neutropenia of Childhood: An Observational Study of Clinical and Laboratory Associations

European Journal of Haematology, EarlyView.
ABSTRACT Objectives To investigate circulating regulatory T cells (Tregs) in children with autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) and evaluate their associations with clinical and laboratory features of neutropenia. Methods Plasma and Peripheral Blood Mononuclear Cells (PBMCs) were collected from 69 participants.
Konstantina Toutoudaki, Elena E. Solomou, Marianna Tzanoudaki, Stavros Glentis, Panagiota Perari, Panagiota Davoulou, Eftichia Theodoropoulou, Polyxeni Delaporta, Eleni Stamou, Irene Mavroudi, Charalambos Pontikoglou, Helen Papadaki, Antonis Kattamis   +12 more
wiley   +1 more source

Endoplasmic reticulum stress in Hashimoto’s thyroiditis: a candidate amplification node linking thyroid-specific vulnerability and immune dysregulation

Frontiers in Immunology
Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune thyroid disease, characterized by lymphocytic infiltration and destruction of thyroid follicular architecture.
Xinying Si, Xinying Si, Zhixun Guo, Gena Jiao, Xiaomei Zhang, Xiaomei Zhang, Yaxue Ge, Jiahui Qian, Xinyi Li, Wenqian Geng, Simiao Yao, Simiao Yao, Zhiguo Ding, Zhiguo Ding, Yanke Wu, Yanke Wu   +15 more
doaj   +1 more source