Results 51 to 60 of about 855,276 (306)

Interplay between cardiovascular and thyroid dysfunctions: A review of clinical implications and management strategies

Endocrine Regulations, 2022
Cardiovascular diseases (CVD) and thyroid dysfunction are two of the most prevailing disorders in the world that are closely interlinked. Actions of thyroid hormones are mediated via thyroid receptors present in the myocardium and the vascular tissue ...
Debmalya Sanyal, Saumitra Ray, Singh Malhi Harshveer   +2 more
doaj   +1 more source

Evaluation of Thyroid Dysfunction in Type 2 DM in Duhok Governorate

Advanced Medical Journal, 2022
Background and Objectives Thyroid diseases and Diabetes are the most common endocrinal disorders seen in clinical practice. As a result, it is common for an individual to be affected by both thyroid diseases and diabetes. Most studies show an increased
Sefar Mohamad Al Haj , Bayar Ahmed Qasim   +1 more
doaj   +1 more source

Immunohistochemistry differentiates papillary thyroid carcinoma arising in ectopic thyroid tissue from secondary lymph node metastases.

, 2007
Objective: To verify whether immunohistochemistry might be useful in the distinction between a true laterocervical metastasis of an undetected thyroid carcinoma and a primary tumor outside the gland.
ARAGONA, Federico, CACCIATORE M, THYROID JUL, CABIBI, Daniela, GUARNOTTA, Carla   +4 more
core   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Prevalence of Thyroid Dysfunction among Patients with Chronic Kidney Disease Attending Diagnostic Laboratory Services, Bulawayo, Zimbabwe

Diversity
Chronic kidney disease (CKD), can alter thyroid hormone production, distribution, and excretion. Thyroid dysfunctions like hypothyroidism, hyperthyroidism, and euthyroidism are identified in renal failure patients.
Lindwe Angela Sibanda, Sundika Makengo Olivier, Idi Doutchi Yacoubou, Aboubacar Katiella Kaka, Maibouge Tanko Mahamane Salissou   +4 more
doaj   +1 more source

The association of thyroid dysfunction with chronic plaque psoriasis: A hospital-based retrospective descriptive observational study

Indian Dermatology Online Journal, 2020
Background: Associations among thyroid dysfunction, thyroid autoimmunity, and clinical features including age, gender, disease duration, and severity of psoriasis is less studied.
Ashwani Rana, Vikram K Mahajan, Pushpinder S Chauhan, Karaninder S Mehta, Satya Bhushan Sharma, Anuj Sharma, Reena Sharma   +6 more
doaj   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Prevalence of thyroid dysfunction in chronic obstructive pulmonary disease patients in a tertiary care center in North India

Journal of Family Medicine and Primary Care, 2018
Introduction: Thyroid dysfunction can cause inspiratory and expiratory muscle weakness in patients with or without chronic obstructive pulmonary disease (COPD) Thyroid dysfunction in COPD results in increased frequency of exacerbation thus lead to poor ...
Shyam Chand Chaudhary, Tauhid Ahmad, Kauser Usman, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Ajay Kumar Verma, D Himanshu Reddy   +6 more
doaj   +1 more source