Results 61 to 70 of about 155,166 (304)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Lenvatinib for Anaplastic Thyroid Cancer and Lenvatinib-Induced Thyroid Dysfunction [PDF]

Background: Lenvatinib is an oral multitargeted tyrosine kinase inhibitor that has an anticancer action in patients with differentiated thyroid cancer that is refractory to radioiodine.
2191, 藤原, 和典, 福原, 隆宏, フクハラ, タカヒロ, 26631, キタノ, ヒロヤ, フジワラ, カズノリ, 小山, 哲史, コヤマ, サトシ, Morisaki, Tsuyoshi, 三宅, 成智, 100001499, 100002206, 26630, Koyama, Satoshi, 3674, 80403418, 40197273, 90403419, 100001318, 4942, 26629, Fujiwara, Kazunori, Fukuhara, Takahiro, Miyake, Naritomo, Takeuchi, Hiromi, Kitano, Hiroya, ミヤケ, ナリトモ, 60464278, タケウチ, ヒロミ, 竹内, 裕美, 100000179, 369, 405, 100000417   +34 more
core   +1 more source

Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. [PDF]

, 2018
Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4.
Collet, Tinh-Hai, Gencer, Baris, Rodondi, Nicolas, Floriani, Carmen   +3 more
core   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

N-TerminalPro-B-TypeNatriuretic Peptide For Detecting Early Cardiac Dysfunction in Patients with Thyroid Dysfunction

, 2013
Aim: The aim of this study was to investigate N-terminal probrain natriuretic peptide (NT-proBNP) as a marker of early cardiac dysfunction in patients with hypothyroidism or hyperthyroidism without any clinical and echocardiographic cardiac problem ...
Şamil Gerek, Makbule Ulusoy, Macit Koldaş   +2 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Prevalence of Thyroid Dysfunction among Patients with Chronic Kidney Disease Attending Diagnostic Laboratory Services, Bulawayo, Zimbabwe

Diversity
Chronic kidney disease (CKD), can alter thyroid hormone production, distribution, and excretion. Thyroid dysfunctions like hypothyroidism, hyperthyroidism, and euthyroidism are identified in renal failure patients.
Lindwe Angela Sibanda, Sundika Makengo Olivier, Idi Doutchi Yacoubou, Aboubacar Katiella Kaka, Maibouge Tanko Mahamane Salissou   +4 more
doaj   +1 more source

Prevalence of thyroid dysfunction in chronic obstructive pulmonary disease patients in a tertiary care center in North India

Journal of Family Medicine and Primary Care, 2018
Introduction: Thyroid dysfunction can cause inspiratory and expiratory muscle weakness in patients with or without chronic obstructive pulmonary disease (COPD) Thyroid dysfunction in COPD results in increased frequency of exacerbation thus lead to poor ...
Shyam Chand Chaudhary, Tauhid Ahmad, Kauser Usman, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Ajay Kumar Verma, D Himanshu Reddy   +6 more
doaj   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

The association of thyroid dysfunction with chronic plaque psoriasis: A hospital-based retrospective descriptive observational study

Indian Dermatology Online Journal, 2020
Background: Associations among thyroid dysfunction, thyroid autoimmunity, and clinical features including age, gender, disease duration, and severity of psoriasis is less studied.
Ashwani Rana, Vikram K Mahajan, Pushpinder S Chauhan, Karaninder S Mehta, Satya Bhushan Sharma, Anuj Sharma, Reena Sharma   +6 more
doaj   +1 more source