Results 61 to 70 of about 230,472 (304)

Electrochemically Engineered PEDOT:PSS/MXene Composite Electrode for the Label‐Free Procalcitonin Detection

Advanced Materials Interfaces, EarlyView.
Procalcitonin is a key biomarker for bacterial infections, but conventional detection methods are often time‐consuming. Here, we present an electrochemical sensor based on highly conductive Ti3C2Tx MXene combined with PEDOT:PSS, enabling direct antibody immobilization, while a bovine serum albumin coating provides antifouling protection.
Angelika Banaś, Roman Turczyn, Maciej Krzywiecki, Izabela Matuła, Sara Shakibania, Katarzyna Krukiewicz, Deivasigamani Ranjith Kumar   +6 more
wiley   +1 more source

Hyperuricemia as cardiovascular risk factor in patients with hypothyroidism [PDF]

, 2016
Thyroid dysfunction is associated with dyslipidemia, a well-known cardiovascular risk factor. Besides dyslipidemia, thyroid dysfunction can induce insulin resistance, hypertension, endothelial dysfunction.
Chukwunonso, Arinze, Obinna, Nwokiea Chukwuma   +1 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Evaluation of renal perfusion in hyperthyroid cats before and after radioiodine treatment [PDF]

, 2017
Background: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important
Adams, Adams, Becker, Boag, Brown, Daniel, Debruyn, Dong, Dong, Fischer, Gauthier, Graves, Grenier, Haers, Herget-Rosenthal, Hoek, Hoek, Hyvelin, Kay, Ma, Milner, Ohlerth, Paepe, Paepe, Peterson, Riensche, Slater, Stock, Stock, Stock, Tang, Tsuruoka, Vaske, Volckaert, Williams   +34 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Prevalence of Thyroid Dysfunction among Patients with Chronic Kidney Disease Attending Diagnostic Laboratory Services, Bulawayo, Zimbabwe

Diversity
Chronic kidney disease (CKD), can alter thyroid hormone production, distribution, and excretion. Thyroid dysfunctions like hypothyroidism, hyperthyroidism, and euthyroidism are identified in renal failure patients.
Lindwe Angela Sibanda, Sundika Makengo Olivier, Idi Doutchi Yacoubou, Aboubacar Katiella Kaka, Maibouge Tanko Mahamane Salissou   +4 more
doaj   +1 more source

Prevalence of thyroid dysfunction in chronic obstructive pulmonary disease patients in a tertiary care center in North India

Journal of Family Medicine and Primary Care, 2018
Introduction: Thyroid dysfunction can cause inspiratory and expiratory muscle weakness in patients with or without chronic obstructive pulmonary disease (COPD) Thyroid dysfunction in COPD results in increased frequency of exacerbation thus lead to poor ...
Shyam Chand Chaudhary, Tauhid Ahmad, Kauser Usman, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Ajay Kumar Verma, D Himanshu Reddy   +6 more
doaj   +1 more source

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study [PDF]

, 2016
Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to ...
Atkin, Stephen L., Bhasin, Shalender, Kilpatrick, Eric S., Rigby, Alan S., Sathyapalan, Thozhukat, Thatcher, Natalie J.   +5 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source