Results 61 to 70 of about 855,276 (306)

Review of the risks and/or benefits of thyroxine treatment in ‘mild’ subclinical hypothyroidism [PDF]

, 2013
Subclinical hypothyroidism (SCH) is a form of mild thyroid failure and is a commonly encountered condition in clinical practice. It denotes the presence of a raised serum thyroid stimulating hormone (TSH) and normal serum free thyroid hormone ...
Agius, Rachel
core  

Lenvatinib for Anaplastic Thyroid Cancer and Lenvatinib-Induced Thyroid Dysfunction [PDF]

Background: Lenvatinib is an oral multitargeted tyrosine kinase inhibitor that has an anticancer action in patients with differentiated thyroid cancer that is refractory to radioiodine.
2191, 藤原, 和典, 福原, 隆宏, フクハラ, タカヒロ, 26631, キタノ, ヒロヤ, フジワラ, カズノリ, 小山, 哲史, コヤマ, サトシ, Morisaki, Tsuyoshi, 三宅, 成智, 100001499, 100002206, 26630, Koyama, Satoshi, 3674, 80403418, 40197273, 90403419, 100001318, 4942, 26629, Fujiwara, Kazunori, Fukuhara, Takahiro, Miyake, Naritomo, Takeuchi, Hiromi, Kitano, Hiroya, ミヤケ, ナリトモ, 60464278, タケウチ, ヒロミ, 竹内, 裕美, 100000179, 369, 405, 100000417   +34 more
core   +1 more source

Acoustic radiation force impulse imaging for differentiation of thyroid nodules [PDF]

, 2012
Background: Acoustic Radiation Force Impulse (ARFI)-imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness.
Stefan Zeuzem, Lisa Voelkl (139194), Holzer, Katharina, Katharina Holzer (139190), Schroeter, Hartmut, Friedrich-Rust, Mireen, Dauth, Nina, Christian Berner, Katharina Holzer, Joerg Bojunga, Gesine Meyer (139188), Hartmut Schroeter (139199), Joerg Bojunga (139182), Berner, Christian, Meyer, Gesine, Lisa Voelkl, Herrmann, Eva, Nina Dauth (139184), Hartmut Schroeter, Voelkl, Lisa, Nina Dauth, Mireen Friedrich-Rust, Bojunga, Jörg, Eva Herrmann (139197), Gesine Meyer, Christian Berner (139186), Eva Herrmann, Mireen Friedrich-Rust (139200), Zeuzem, Stefan, Stefan Zeuzem (22856)   +29 more
core   +2 more sources

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Risk-Based Screening for Thyroid Dysfunction during Pregnancy

Journal of Pregnancy, 2013
Objective. We conducted the study to see the incidence of thyroid dysfunction in women with obstetrical high-risk factors. Methods. We retrospectively reviewed medical charts of high-risk pregnant women who had examination for thyroid function during ...
Masanao Ohashi, Seishi Furukawa, Kaori Michikata, Katsuhide Kai, Hiroshi Sameshima, Tsuyomu Ikenoue   +5 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Impact of thyroid dysfunction and diabetes on fibrosis and steatosis stages in metabolic dysfunction associated fatty liver disease

Scientific Reports
Metabolic dysfunction associated fatty liver disease (MAFLD) is a common metabolic disorder intricately linked to diabetes and thyroid dysfunction. Hypothyroidism, characterized by elevated thyroid-stimulating hormone (TSH), may disrupt lipid metabolism ...
Mohamed W. Saleh, Maysa I. Farghly, Eman Elsebaie, Nessren Mohamed, Eman El-Mankhly   +4 more
doaj   +1 more source

Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia

International Journal of Endocrinology, 2019
Background. Thyroid dysfunction is the most common endocrine disorder in clinical practice, and about half of the population with thyroid dysfunction remains undiagnosed.
Daniel Asmelash, Kumlgn Tesfa, Belete Biadgo   +2 more
doaj   +1 more source

Analyzing thyroid dysfunction in the climacteric

Journal of Mid-life Health, 2018
Perimenopause and menopause is an integral part of every woman's life constituting about 30% of the Indian female population. Hypothyroidism is a condition that can mimic menopausal symptoms very often. Therefore, routine screening of thyroid function in the climacteric and menopausal period to determine subclinical thyroid disease can be recommended ...
Subrat Panda, Ananya Das
openaire   +3 more sources