Results 71 to 80 of about 855,276 (306)

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Thyroid Dysfunction among Patients with Diabetes Mellitus in Kathmandu

Journal of College of Medical Sciences-Nepal, 2018
Background: This study was conducted with the objective of studying thyroid dysfunction in patients with diabetes mellitus. Materials & Methods: A total 100 patients consisting of 40males and60females diagnosed as diabeteswere included in the study ...
Khema Raj Bhusal, Pratap Pokhrel, Rabindra Simkhada   +2 more
doaj   +1 more source

N-TerminalPro-B-TypeNatriuretic Peptide For Detecting Early Cardiac Dysfunction in Patients with Thyroid Dysfunction

, 2013
Aim: The aim of this study was to investigate N-terminal probrain natriuretic peptide (NT-proBNP) as a marker of early cardiac dysfunction in patients with hypothyroidism or hyperthyroidism without any clinical and echocardiographic cardiac problem ...
Şamil Gerek, Makbule Ulusoy, Macit Koldaş   +2 more
core   +1 more source

Thyroid dysfunction and immune checkpoint inhibitor outcomes.

, 2020
Background: Immune checkpoint inhibitors (ICI) frequently cause thyroid dysfunction. We performed a longitudinal analysis of thyroid function tests in a large, single-center cohort of patients with multiple cancer types receiving ICI.
Ali, Sadia, Xie, Yang, Gerber, David E, Cai, Jennifer, Lu, Rong, Xie, Donglu, von Itzstein, Mitchell S   +6 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Prevalence and clinical characterisation of thyroid dysfunction in COPD: a systematic review and meta-analysis

Frontiers in Medicine
BackgroundThe prevalence of COPD is increasing annually, accompanied by a growing number of complications and organ function abnormalities. Thyroid dysfunction is prevalent among patients with chronic obstructive pulmonary disease (COPD).
Ling Wu, Li He, Xiaorong Hu, Hanqiong Zhang, Zeming He, Xiaotao Huang, Caihong Li, Yong Zhang   +7 more
doaj   +1 more source

THYROID DYSFUNCTION

The Professional Medical Journal, 2011
Objectives: Studies on relation between serum lipids and thyroid dysfunction are numerous but, on the whole, desultory and inconclusive. The aim of this study was to investigate the concentration of serum triglyceride, cholesterol and cholesterol profile in Sudanese patient with thyroid dysfunction. Design: A case control study.
ABDELMULA M. ABDELLA, GAD ALLAH MODAWE
openaire   +2 more sources

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Development of thyroid dysfunction is associated with clinical response to PD-1 blockade treatment in patients with advanced non-small cell lung cancer

OncoImmunology, 2018
Purpose: Drugs that blockade interaction between programmed cell-death protein 1 (PD-1) and its ligand (PD-L1) are promising. Immune-related adverse events (irAEs) might be associated with favorable clinical outcomes, and thyroid dysfunction is one of ...
Hye In Kim, Mijin Kim, Se-Hoon Lee, So Young Park, Young Nam Kim, Hosu Kim, Min Ji Jeon, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Sang-We Kim, Dae Ho Lee, Keunchil Park, Myung-Ju Ahn, Jae Hoon Chung, Young Kee Shong, Won Gu Kim, Tae Hyuk Kim   +17 more
doaj   +1 more source

Psychological well-being on thyroid hormone replacement [PDF]

Despite 100 years after the discovery of thyroxine, controversy still exists regarding optimal thyroid hormone replacement therapy. Several anecdotal reports suggest that thyroxine alone therapy does not normalise psychological wellbeing.
Saravanan, Ponnusamy
core