Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]
, 2006 Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel +6 more
core +1 more source
Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities
Advanced Science, EarlyView.Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen +18 more
wiley +1 more source
Systematic review of ocular surface treatments in the setting of thyroid eye disease
Frontiers in OphthalmologyIntroductionApproximately 85% of patients with thyroid eye disease experience ocular surface symptoms. Although corneal exposure plays a role in inducing inflammatory changes to the ocular surface, multiple studies reveal more complexity to the abnormal ...
Anthony Stephen Wong +2 more
doaj +1 more source
Use of Best Practice Alerts to Improve Adherence to Evidence-Based Screening in Pediatric Diabetes Care [PDF]
, 2019 Background: Youth with type 1 diabetes (T1D) are at increased risk for comorbid autoimmune conditions and long-term complications. To help with early identification of these complications, the American Diabetes Association (ADA) has published evidence ...
Bartz, Sara K +3 more
core +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Evaluation of corneal transplantation [PDF]
, 1997 Editorial / comment on corneal ...
Coster, Douglas John
core +1 more source
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Медицинская иммунология, 2017 We searched for a possible target tissue in eye orbit for thyroid autoantibodies in endocrine ophthalmopathy (Graves’ disease), using correlation analysis method. We examined a group of 139 patients (278 eye orbits) with thyroid-associated ophthalmopathy
V. G. Likhvantseva +4 more
doaj +1 more source
Pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism in a patient with selective L-thyroxine malabsorption [PDF]
, 2017 We present the case of a 29-year-old woman who developed a severe hypothyroidism induced by a thyroxine malabsorption and a secondary pituitary hyperplasia.
Romanelli, Francesco +4 more
core +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Advanced Science, EarlyView.This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source