Results 41 to 50 of about 5,957,667 (290)

Systematic review of ocular surface treatments in the setting of thyroid eye disease

Frontiers in Ophthalmology
IntroductionApproximately 85% of patients with thyroid eye disease experience ocular surface symptoms. Although corneal exposure plays a role in inducing inflammatory changes to the ocular surface, multiple studies reveal more complexity to the abnormal ...
Anthony Stephen Wong, James G. Chelnis, James G. Chelnis   +2 more
doaj   +1 more source

How patients experience thyroid eye disease

Frontiers in Endocrinology, 2023
ObjectiveTo determine the impact of thyroid eye disease (TED) on patients in various stages of the disease.BackgroundTED is a debilitating and potentially sight-threatening inflammatory autoimmune disease that is frequently misdiagnosed.
Terry J. Smith, Laszlo Hegedüs, Ira Lesser, Petros Perros, Kimberly Dorris, Michele Kinrade, Patti Troy-Ott, Laura Wuerth, Mukund Nori   +8 more
doaj   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Aggravated Orbitopathy Following Remnant Ablation in a Patient with Multiple Cancers

Endocrinology Research and Practice, 2017
The rate of thyroid cancer in the patients with Graves’ disease is controversial. The rare incidents of multiple primary thyroid cancers in the same patient have been reported.
Umut MOUSA, Hasan SAV, Osman KÖSEOĞULLARI, Şebnem AYDIN, Hanife ÖZKAYALAR   +4 more
doaj   +1 more source

An algorithm for Botulinum toxin A injection for upper eyelid retraction associated with thyroid eye disease: long-term results

, 2020
Purpose To evaluate the efficacy and complications of transconjunctival Botulinum toxin A injections performed according to an algorithm, for the management of upper eyelid retraction associated with thyroid eye ...
Ozturker, Can, Taskapili, Muhittin, Gunaydin, Zehra Karaagac, Kaynak, Pelin, Fazil, Korhan, Saracoglu Yilmaz, Basak, Karabulut, Gamze Ozturk, Pelin Kaynak, Muhittin Taskapili, Can Ozturker, Zehra Karaağaç Günaydın, Korhan Fazil, Basak Saracoglu Yilmaz, Gamze Ozturk Karabulut   +13 more
core   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation?

Indian Journal of Ophthalmology, 2020
Purpose: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. Methods: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty ...
Lakshmi B Ramamurthy, Viji Rangarajan, Neha Srirao, Bindu Malini, Renu Bansal, Kavitha Yuvarajan   +5 more
doaj   +1 more source

Orbital radiotherapy for adult thyroid eye disease

, 2012
Thyroid eye disease is an autoimmune inflammatory condition of the orbital and periorbital tissues. Orbital radiotherapy is an anti-inflammatory treatment used in the treatment of active thyroid eye disease.
Bunce, Catey, Lee, Richard W J, Morley, Ana M S, Rajendram, Rathie   +3 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Thyroid Eye Disease as a Mimic

, 2022
Dr.
Andrew G. Lee, MD
core