Results 41 to 50 of about 467,067 (355)

The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions

Frontiers in Endocrinology
The thyroid gland regulates most of the physiological processes. Environmental factors, including climate change, pollution, nutritional changes, and exposure to chemicals, have been recognized to impact thyroid function and health. Thyroid disorders and
Maria E. Street, Maria E. Street, Anna-Mariia Shulhai, Maddalena Petraroli, Viviana Patianna, Valentina Donini, Antonella Giudice, Margherita Gnocchi, Marco Masetti, Anna G. Montani, Roberta Rotondo, Sergio Bernasconi, Lorenzo Iughetti, Susanna M. Esposito, Susanna M. Esposito, Barbara Predieri   +15 more
doaj   +1 more source

The function of the thyroid gland in patients with multi-drug resistant tuberculosis

Antimicrobial Resistance and Infection Control, 2017
Background Multidrug-resistant tuberculosis (MDRTB) remains a health problem for many countries in the world. The share of MDRTB is 10–30% among newly diagnosed cases and 20–70% among relapses and treatment failure.
S. L. Matveyeva, O. S. Shevchenko, O. O. Pogorelova   +2 more
doaj   +1 more source

Monitoring thyroid function status in elderly patients on amiodarone [PDF]

, 2006
Objectives: To evaluate whether elderly patients on amiodarone were having their thyroid function status monitored as recommended in the literature and to identify the frequency and type of thyroid function test abnormalities noted.
Fiorini, Anthony
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]

, 2010
Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques, Defrise, Michel, Franken, Philippe R, Guglielmi, Julien, Koulibaly, Malick, Pourcher, Thierry, Vanhove, Christian   +6 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Evaluating of Thyroid Function Tests and Thyroid Autoantibodies in Patients with Allergic Rhinitis

İstanbul Medical Journal, 2017
Introduction: Allergic rhinitis is a common chronic allergic disease. The effects of allergic diseases on autoimmune diseases are not known. The patients are predisposed to react to exogenic antigens in allergic diseases and they can more easily react to
Feridun Gürlek, Eyyüp Taşdemir
doaj   +1 more source

Serum thyroid hormone levels in preeclampsia women in Gorgan [PDF]

, 2014
Etiology of preeclampsia is clearly unknown. The aim of this study was to assess thyroid hormone levels in mild and severe preeclampsia women and compare them with healthy pregnant women.
Marjani, A., Rafeeinia, A., Teymoori, H.
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source