Results 51 to 60 of about 12,755,878 (352)

Maternal thyroid function during pregnancy and child brain morphology: a time window-specific analysis of a prospective cohort.

The Lancet Diabetes and Endocrinology, 2019
BACKGROUND Adequate thyroid hormone availability during pregnancy is necessary for optimal fetal brain development. During the first 18-20 weeks of gestation, fetal thyroid hormone availability largely depends on the placental transfer of maternal ...
Toyah A. Jansen, T. Korevaar, Tessa A M Mulder, T. White, R. Muetzel, R. Peeters, H. Tiemeier   +6 more
semanticscholar   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

HUBUNGAN FUNGSITIROID DENGAN GANGGUAN PENDENGARAN PADA ANAK SINDROM DOWN [PDF]

, 2015
Background: Children with Down syndrome have increased risk of health problems. Two common health problems in children with Down syndrome are thyroid dysfunction and hearing disorder.
Margono, Irwan Arif, Purwanti, Asri, Widodo, Pujo   +2 more
core   +1 more source

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome [PDF]

, 2014
Background/Aims: The natural history of thyroid function in children with Down's syndrome is relatively unknown. We hypothesized that in these patients the occurrence of thyroid dysfunction rises during development. Methods: Thyroid function was assessed
Bedogni G, Biagioni O, Bozzola M., BRUZZI, Patrizia, Garavelli L, IUGHETTI, Lorenzo, Madeo SF, PREDIERI, Barbara, PREDIERI, Flavia, Vellani G   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Associations between cardiovascular health and low thyroid function among US adults: a population-based study

Frontiers in Endocrinology
BackgroundHigher thyroid-stimulating hormone (TSH) amidst normal thyroid hormone (TH) levels may contribute to a negative impact on cardiovascular health (CVH).
Xiaoxiao Fang, Xiaoxiao Fang, Rui Hu, Shani Fei, Zhiguo Ding, Jiuli Zhao, Jianwei Shang   +6 more
doaj   +1 more source

Zn(II)-curc targets p53 in thyroid cancer cells [PDF]

, 2015
P53 mutation is a common event in many cancers, including thyroid carcinoma. Defective p53 activity promotes cancer resistance to therapies and a more malignant phenotype, acquiring oncogenic functions.
Crispini, Alessandra, D'Orazi, Gabriella, D'Orazi, Valerio, Garufi, Alessia   +3 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Predicting risk of malignancy in patients with indeterminate thyroid nodules [PDF]

, 2018
Thyroid cancer is the most prevalent endocrine cancer (1). The prevalence of palpable thyroid nodules in the general adult population is 4% to 7% (2). Ultrasound imaging detects thyroid nodules in 19%-68% of randomly selected individuals (3). The rate of
Carnes, Nicholas
core  

Maternal thyroid function and child educational attainment: prospective cohort study [PDF]

, 2018
Objective: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. Design: Prospective cohort study.
Haig, Caroline, Lawlor, Debbie A., Lindsay, Robert S., McConnachie, Alex, Nelson, Scott M., Ring, Susan M., Sattar, Naveed, Smith, George D.   +7 more
core   +3 more sources