Results 41 to 50 of about 5,895,005 (299)

The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions

Frontiers in Endocrinology
The thyroid gland regulates most of the physiological processes. Environmental factors, including climate change, pollution, nutritional changes, and exposure to chemicals, have been recognized to impact thyroid function and health. Thyroid disorders and
Maria E. Street, Maria E. Street, Anna-Mariia Shulhai, Maddalena Petraroli, Viviana Patianna, Valentina Donini, Antonella Giudice, Margherita Gnocchi, Marco Masetti, Anna G. Montani, Roberta Rotondo, Sergio Bernasconi, Lorenzo Iughetti, Susanna M. Esposito, Susanna M. Esposito, Barbara Predieri   +15 more
doaj   +1 more source

The function of the thyroid gland in patients with multi-drug resistant tuberculosis

Antimicrobial Resistance and Infection Control, 2017
Background Multidrug-resistant tuberculosis (MDRTB) remains a health problem for many countries in the world. The share of MDRTB is 10–30% among newly diagnosed cases and 20–70% among relapses and treatment failure.
S. L. Matveyeva, O. S. Shevchenko, O. O. Pogorelova   +2 more
doaj   +1 more source

The link between thyroid function and depression

, 2012
The relation between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities ...
Azar S.T., Hage M.P.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Associations between cardiovascular health and low thyroid function among US adults: a population-based study

Frontiers in Endocrinology
BackgroundHigher thyroid-stimulating hormone (TSH) amidst normal thyroid hormone (TH) levels may contribute to a negative impact on cardiovascular health (CVH).
Xiaoxiao Fang, Xiaoxiao Fang, Rui Hu, Shani Fei, Zhiguo Ding, Jiuli Zhao, Jianwei Shang   +6 more
doaj   +1 more source

External radiotherapy of thyroid cancer [PDF]

, 2001
Differentiated thyroid cancer comprises papillary, mixed papillary-follicular and follicular adenocarcinomas. They are mostly hormone-sensitive and respond to thyroid-stimulating hormone (TSH) suppression. The standard treatment is total thyroidectomy. I-
Pollinger, B., Dühmke, Eckhart
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer [PDF]

, 2009
Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in
Steward DL, Tuttle RM, Schlumberger M, Martin Schlumberger, Stephanie L. Lee, Haugen, Bryan R., McIver B, Cooper, David S., Haugen BR, Cooper DS, American Thyroid Association Guidelines Taskforce on Thyroid Nodules, Mandel, Susan J., Steward, David L., Bryan McIver, Richard T. Kloos, Mazzaferri EL, Steven I. Sherman, Doherty, Gerard M., Sherman, Steven I., Susan J. Mandel, Lee SL, Kloos RT, R. Michael Tuttle, McIver, Bryan, Ernest L. Mazzaferri, Kloos, Richard T., Lee, Stephanie L., Gerard M. Doherty, Pacini, Furio, Doherty GM, Bryan R. Haugen, Schlumberger, Martin, Furio Pacini, Differentiated Thyroid Cancer, David S. Cooper, Mazzaferri, Ernest L., Mandel SJ, Sherman SI, David L. Steward, Tuttle, R. Michael   +39 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Role of Pax8 transcriptional factor in the differentiated thyroid [PDF]

, 2010
In Pax8-/- mice the thyroid anlage disappears around E11.5. At birth the gland appears as a rudimentary structure composed only of C cells while thyroid follicular cells are undetectable. Thus, this model does not allow the study of Pax8 function in the
Marotta, Pina
core   +1 more source