Results 51 to 60 of about 335,864 (307)

Peripheral thyroid hormone levels and hepatic thyroid hormone deiodinase gene expression in dairy heifers on the day of ovulation and during the early peri-implantation period [PDF]

, 2016
Background: Before the onset of fetal thyroid hormone production, the transplacental delivery of maternal thyroid hormones is necessary for embryonic and fetal development. Therefore, the adaptation of maternal thyroid hormone metabolism may be important
Hoedemaker, Martina, Linden, Matthias, Mense, Kirsten, Meyerholz, Marie Margarete, Raliou, Miriam, Sandra, Olivier, Schmicke, Marion, Schuberth, Hans-Joachim   +7 more
core   +2 more sources

Thyroid hormone receptors and resistance to thyroid hormone disorders [PDF]

Nature Reviews Endocrinology, 2014
Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal
Tânia M, Ortiga-Carvalho, Aniket R, Sidhaye, Fredric E, Wondisford   +2 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Thyroid Hormone Therapy for Potential Heart Donors: A Comprehensive Review of Clinical Trials

Biomedicines
Background: Due to neurohormonal disturbances that occur following brain death, thyroid hormone therapy has been proposed as a means to enhance cardiac function in brain-dead organ donors.
Mushood Ahmed, Eeshal Zulfiqar, Sonia Hurjkaliani, Aimen Shafiq, Hafsa Arshad Azam Raja, Areeba Ahsan, Aemen Kamran, Laveeza Fatima, Amna Nadeem, Muhammad Abdullah Naveed, Faizan Ahmed, Hritvik Jain, Tallal Mushtaq Hashmi, Muath Baniowda, Mansimran Singh Dulay, Sivaram Neppala, Himaja Dutt Chigurupati, Ali Hasan, Peter Collins, Raheel Ahmed   +19 more
doaj   +1 more source

Prediction of Thyroid Hormone Replacement Following Thyroid Lobectomy: A Long-term Retrospective Study

OTO Open, 2021
Objective Following thyroid lobectomy, patients are at risk for hypothyroidism. This study sought to determine the incidence of postlobectomy thyroid hormone replacement as well as predictive risk factors to better counsel patients.
Charles Meyer MD, Danielle Anderson DO, Zhiqiao Dong, Jeanelle Braxton Riddick MPA, Marilisa Elrod MD, PhD, Marco Ayala MD   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm

Gynecology and Minimally Invasive Therapy, 2017
We report struma ovarii in a case that had hyperthyroidism and was treated with laparoscopic tumor resection. A 40-year-old Japanese woman presented with tachycardia, finger tremor, and weight loss. Although blood examination showed hyperthyroidism, test
Koichi Nagai, Hiroshi Yoshida, Kayo Katayama, Yumi Ishidera, Yuka Oi, Noriko Ando, Hiroyuki Shigeta   +6 more
doaj   +1 more source

Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults [PDF]

, 2015
Background Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are worldwide treatment options for multinodular non-toxic goitre in adults.
Arezzo, Alberto, Avenia, Nicola, Barczyñski, Marcin, Cirocchi, Roberto, D'Andrea, Vito, DI ROCCO, Giorgio, Guarino, Salvatore, Randolph, Justus, Santoro, Alberto, Trastulli, Stefano   +9 more
core   +2 more sources

Thyroid hormone replacement after thyroid lobectomy [PDF]

Surgery, 2009
The purpose of this study was to determine the incidence of and identify risk factors for postoperative hypothyroidism in patients undergoing thyroid lobectomy.We retrospectively reviewed patients who underwent a thyroid lobectomy for benign disease from May 2004 to December 2007.
Samantha J, Stoll, Susan C, Pitt, Jing, Liu, Sarah, Schaefer, Rebecca S, Sippel, Herbert, Chen   +5 more
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source