Results 61 to 70 of about 583,270 (252)

Disrupted thyroid hormone homeostasis in critical illness: clinical correlates and associations with hormone supplementation in a single-center retrospective observational study

Anaesthesiology Intensive Therapy
Background Thyroid hormone disturbances are a hallmark of critical illness and are commonly attributed to non-thyroidal illness syndrome. The clinical relevance of thyroid hormone supplementation in the intensive care unit (ICU) remains uncertain.
Alicja Filipczyk, Szymon Zdanowski, Jan Kasprzyk, Karolina Niedzielska, Artur Rakhatsevich, Magdalena Anna Wujtewicz, Tomasz J. Stefaniak, Karol P. Steckiewicz   +7 more
doaj   +1 more source

Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

Urinary phytoestrogen levels and reduced thyroid hormone sensitivity: a cross-sectional analysis of NHANES 2007–2010

European Journal of Medical Research
Background Estrogen and thyroid hormone interact extensively in vivo, but the relationship between phytoestrogens and thyroid function and thyroid hormone sensitivity remains unclear.
Zongbao Li, Fan Hu, Han Yu, Yao Yao, Yanhui Lu   +4 more
doaj   +1 more source

Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males

International Journal of Endocrinology, 2022
Objectives. Thyroid hormone is acknowledged as a pivotal factor in skeletal development and adult bone maintenance. However, available data about the relationship between sensitivity to thyroid hormone and bone mineral density (BMD) remain limited and ...
Shuai Chen, Wucui Huang, Guowei Zhou, Xiaohe Sun, Jie Jin, Zhiwei Li   +5 more
doaj   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Sick euthyroid syndrome: A myth or reality

Journal of Pediatric Critical Care, 2017
Altered thyroid function in non-thyroidal illness(NTI) is a well-recognized finding. The term euthyroid sick syndrome (SES) identifies abnormalities in thyroid function observed in patients with systemic nonthyroidal illnesses (NTIs).
Vinayak Patki, Aniket Kumbhojkar, Praveen Khilnani   +2 more
doaj   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Resistance to thyroid hormone beta (R243Q) with autoimmune primary hypothyroidism: report of a kindred [PDF]

Archives of Endocrinology and Metabolism
The syndrome of resistance to thyroid hormone beta (RTHβ) is characterized by impaired tissue responsiveness to thyroid hormone and manifests as non-suppressed thyrotropin despite elevated thyroid hormone levels.
Alpesh Goyal, Rahul Gupta, Rekha Singh
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism

BJS (British Journal of Surgery), EarlyView., 2020
Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz, S. van Slycke, Ö. Makay, L. Brunaud   +3 more
wiley   +1 more source