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Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production [PDF]
JCI Insight, 2021 Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant ...
Sujie Ke +7 more
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Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis [PDF]
Endocrine Connections, 2018 Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling ...
Christin Krause +7 more
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Drug discovery targeting thyroid hormone receptor β (THRβ) for the treatment of liver diseases and other medical indications [PDF]
Acta Pharmaceutica Sinica BThyroid hormone receptors (THRs), a crucial nuclear receptor protein family, primarily consist of two categories: α receptors and β receptors. Among them, THRβ is the primary subtype of thyroid hormone that confers benefits to the liver.
Kean Wang +3 more
doaj +2 more sources
Thyroid hormone resistance beta and autoimmune thyroid disease - a family case study highlighting diagnostic and therapeutic challenges [PDF]
Cardiovascular Diabetology. Endocrinology ReportsBackground Resistance to thyroid hormone (RTH) is a rare endocrine disorder, most commonly caused by mutations in the thyroid hormone receptor β (TRβ) gene, resulting in the RTH beta (RTHβ) subtype.
Mirjana Đukić +3 more
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Ecotoxicology and Environmental Safety, 2022 Cadmium is a ubiquitous environmental pollutant, which can increase the risk of preeclampsia. This study was designed to determine the mechanism of cadmium exposure during pregnancy impaired placental angiogenesis that was associated with the occurrence ...
Xuan Li +10 more
doaj +1 more source
Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance
Endocrine Connections, 2022 Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann +11 more
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Central hyperthyroidism combined with Graves' disease: case series and review of the literature
European Thyroid Journal, 2023 Background: Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β ...
Caiyan Mo +4 more
doaj +1 more source
Nature Communications, 2022 Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating
Ying Yan +20 more
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The Syndromes of Resistance to Thyroid Hormone Beta
罕见病研究, 2023 The syndrome of resistance to thyroid hormone(RTH) is a rare syndrome caused by the mutation of thyroid hormone receptor (TR) gene, which reduces the sensitivity of target organs to thyroid hormone (TH) and leads to the dysfunction of TH. Thyroid hormone
WANG Huangman +2 more
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Thyroid Hormone Signaling in the Mouse Retina. [PDF]
PLoS ONE, 2016 Thyroid hormone is a crucial regulator of gene expression in the developing and adult retina. Here we sought to map sites of thyroid hormone signaling at the cellular level using the transgenic FINDT3 reporter mouse model in which neurons express β ...
Patrick Arbogast +4 more
doaj +1 more source