Results 1 to 10 of about 948 (200)
Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance
Endocrine Connections, 2022 Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann +11 more
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Thyroid Hormone Signaling in the Mouse Retina. [PDF]
PLoS ONE, 2016 Thyroid hormone is a crucial regulator of gene expression in the developing and adult retina. Here we sought to map sites of thyroid hormone signaling at the cellular level using the transgenic FINDT3 reporter mouse model in which neurons express β ...
Patrick Arbogast +4 more
doaj +3 more sources
Ecotoxicology and Environmental Safety, 2022 Cadmium is a ubiquitous environmental pollutant, which can increase the risk of preeclampsia. This study was designed to determine the mechanism of cadmium exposure during pregnancy impaired placental angiogenesis that was associated with the occurrence ...
Xuan Li +10 more
doaj +1 more source
Central hyperthyroidism combined with Graves' disease: case series and review of the literature
European Thyroid Journal, 2023 Background: Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β ...
Caiyan Mo +4 more
doaj +1 more source
Nature Communications, 2022 Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating
Ying Yan +20 more
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The Syndromes of Resistance to Thyroid Hormone Beta
罕见病研究, 2023 The syndrome of resistance to thyroid hormone(RTH) is a rare syndrome caused by the mutation of thyroid hormone receptor (TR) gene, which reduces the sensitivity of target organs to thyroid hormone (TH) and leads to the dysfunction of TH. Thyroid hormone
WANG Huangman +2 more
doaj +1 more source
Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation [PDF]
Neonatal Medicine, 2019 Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH or in premature infants, and its clinical presentation varies. In our case, a
Joon Yeol Bae +6 more
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Ecotoxicology and Environmental Safety, 2022 Perfluorohexanoic acid (PFHxA) has been recognized as an alternative to the wide usage of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the fluoropolymer industry for years. PFHxA has been frequently detected in the environment due to
Shengnan Zhang +7 more
doaj +1 more source
iScience, 2023 Summary: Agonists for thyroid hormone receptor β (TRβ) show promise in preclinical studies and clinical trials to improve non-alcoholic fatty liver disease.
Nuria Lopez-Alcantara +4 more
doaj +1 more source
JCI Insight, 2021 Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant ...
Sujie Ke +7 more
doaj +1 more source