Results 11 to 20 of about 948 (200)

Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis [PDF]

Endocrine Connections, 2018
Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling ...
Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, Henriette Kirchner   +7 more
doaj   +2 more sources

Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1 [PDF]

Endocrinology and Metabolism, 2015
BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP).
Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park   +10 more
doaj   +3 more sources

Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation

European Thyroid Journal
Background: Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability.
Ferdy S van Geest, Wenjun Liao, Paul G Voorhoeve, Willemijn G Leen, Nitash Zwaveling-Soonawala, V Krishna Chatterjee, Sjoerd A A Van den Berg, Frederik A Verburg, Marcel E Meima, Erica L T van den Akker, W Edward Visser   +10 more
doaj   +2 more sources

Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist

, 2022
The design and development of agonists selectively targeting thyroid hormone receptor β (TRβ) and TRβ mutants remain challenging tasks. In this study, we first adopted the strategy of breaking the “His-Phe switch” to solve two problems, simultaneously. A
Haonan Yu (3750064), Yong Li (15029), Yong Xu (17491), Zhou Lu (652261), Qiuping Xiang (1444801), Qiu Li (2127361), Xiaoxi Zhuang (54231), Donghai Wu (309245), Cheng Zhang (70708), Junhua Li (125998), Benqiang Yao (8840186), Xishan Wu (5051360), Yan Zhang (8098), Shiting Zhao (12500952)   +13 more
core   +10 more sources

Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation

Neoplasia: An International Journal for Oncology Research, 2014
Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated thyroid cancer remains largely unknown.
Xuguang Zhu, Li Zhao, Jeong Won Park, Mark C. Willingham, Sheue-yann Cheng   +4 more
doaj   +2 more sources

A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in the THRB Gene: Experience in Diagnosis and Treatment

International Medical Case Reports Journal
Jie Liu, Yu Wei, Yanhui Zhu, Yu Li, Qiong Wang, Lei Yu, Langen Zhuang, Guoxi Jin, Xiaoyan Pei Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui Province, People’s Republic of ChinaCorrespondence: Guoxi
Liu J, Wei Y, Zhu Y, Li Y, Wang Q, Yu L, Zhuang L, Jin G, Pei X   +8 more
doaj   +2 more sources

A hypothyroid mother after subtotal thyroidectomy delivered a newborn with hyperthyroidism from fetal stage: a case report

BMC Pregnancy and Childbirth, 2022
Background Neonatal hyperthyroidism is an extension of fetal disease. Most cases of neonatal hyperthyroidism are transient but may excessively harm multiple organ functions through the actions of maternal thyroid-stimulating hormone receptor antibodies ...
Cheng Peng, Weijie Sun, Lixin Fan, Li Li, Xiaojiao Zhang, Ying Gao, Xinlin Hou   +6 more
doaj   +1 more source

Graves’ disease coexisted with resistance to thyroid hormone: a case report

Journal of Medical Case Reports, 2021
Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj   +1 more source

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production

Frontiers in Cell and Developmental Biology, 2021
The relationship between thyroid hormones and serum urate is unclear. Our aim is to analyze the correlation between uric acid and thyroid hormones in gout patients and to explore the effect and mechanism of triiodothyronine on liver uric acid production.
Xiaoting Chen, Mian Wu, Nan Liang, Junxi Lu, Shen Qu, Haibing Chen, Haibing Chen   +6 more
doaj   +1 more source

A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves’ disease: a case report

Journal of Medical Case Reports, 2012
Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi, Hiromatsu Yuji, Sasaki Shigekazu, Nakamura Hirotoshi, Katayama Koju, Nishioka Junko, Koga Yasutoshi   +6 more
doaj   +1 more source