Results 11 to 20 of about 2,758,127 (153)

Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation [PDF]

European Thyroid Journal
Background: Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability.
Ferdy S van Geest, Wenjun Liao, Paul G Voorhoeve, Willemijn G Leen, Nitash Zwaveling-Soonawala, V Krishna Chatterjee, Sjoerd A A Van den Berg, Frederik A Verburg, Marcel E Meima, Erica L T van den Akker, W Edward Visser   +10 more
doaj   +3 more sources

A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in the THRB Gene: Experience in Diagnosis and Treatment [PDF]

International Medical Case Reports Journal
Jie Liu, Yu Wei, Yanhui Zhu, Yu Li, Qiong Wang, Lei Yu, Langen Zhuang, Guoxi Jin, Xiaoyan Pei Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui Province, People’s Republic of ChinaCorrespondence: Guoxi
Liu J, Wei Y, Zhu Y, Li Y, Wang Q, Yu L, Zhuang L, Jin G, Pei X   +8 more
doaj   +1 more source

Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation [PDF]

Neonatal Medicine, 2019
Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH or in premature infants, and its clinical presentation varies. In our case, a
Joon Yeol Bae, Dong Yeop Kim, Young Dai Kwon, Young Hwa Song, Han Hyuk Lim, Hyung-Doo Park, Jae Woo Lim   +6 more
doaj   +1 more source

Lack of thyroid hormone receptor beta is not detrimental for non-alcoholic steatohepatitis progression

iScience, 2023
Summary: Agonists for thyroid hormone receptor β (TRβ) show promise in preclinical studies and clinical trials to improve non-alcoholic fatty liver disease.
Nuria Lopez-Alcantara, Rebecca Oelkrug, Sarah Christine Sentis, Henriette Kirchner, Jens Mittag   +4 more
doaj   +1 more source

A hypothyroid mother after subtotal thyroidectomy delivered a newborn with hyperthyroidism from fetal stage: a case report

BMC Pregnancy and Childbirth, 2022
Background Neonatal hyperthyroidism is an extension of fetal disease. Most cases of neonatal hyperthyroidism are transient but may excessively harm multiple organ functions through the actions of maternal thyroid-stimulating hormone receptor antibodies ...
Cheng Peng, Weijie Sun, Lixin Fan, Li Li, Xiaojiao Zhang, Ying Gao, Xinlin Hou   +6 more
doaj   +1 more source

Graves’ disease coexisted with resistance to thyroid hormone: a case report

Journal of Medical Case Reports, 2021
Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj   +1 more source

Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1 [PDF]

Endocrinology and Metabolism, 2015
BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP).
Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park   +10 more
doaj   +1 more source

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production

Frontiers in Cell and Developmental Biology, 2021
The relationship between thyroid hormones and serum urate is unclear. Our aim is to analyze the correlation between uric acid and thyroid hormones in gout patients and to explore the effect and mechanism of triiodothyronine on liver uric acid production.
Xiaoting Chen, Mian Wu, Nan Liang, Junxi Lu, Shen Qu, Haibing Chen, Haibing Chen   +6 more
doaj   +1 more source

A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves’ disease: a case report

Journal of Medical Case Reports, 2012
Introduction Resistance to thyroid hormone is a syndrome caused by thyroid hormone receptor β mutations, which are usually inherited in an autosomal-dominant pattern.
Yatsuga Shuichi, Hiromatsu Yuji, Sasaki Shigekazu, Nakamura Hirotoshi, Katayama Koju, Nishioka Junko, Koga Yasutoshi   +6 more
doaj   +1 more source

An Inhibitor of the Interaction of Thyroid Hormone Receptor β and Glucocorticoid Interacting Protein 1

, 2016
An Inhibitor of the Interaction of Thyroid Hormone Receptor β and Glucocorticoid Interacting Protein
R. Kiplin Guy (160393), Timothy R. Geistlinger (2984055)   +1 more
core   +2 more sources