Results 1 to 10 of about 90,318,030 (246)

Graves’ disease coexisted with resistance to thyroid hormone: a case report [PDF]

Journal of Medical Case Reports, 2021
Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj   +2 more sources

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study [PDF]

EBioMedicine
Summary: Background: Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1 ...
Wenjun Liao, Federica Marelli, Carla Moran, Irene Campi, Stefan Groeneweg, Zainaba Mohamed, Eman Kamaleldeen, Raja Padidela, Catharina Olivius, Luuk Oosterkamp, Selmar Leeuwenburgh, Greta Lyons, Robin P. Peeters, Krishna Chatterjee, Luca Persani, Marcel Meima, W. Edward Visser   +16 more
doaj   +2 more sources

Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation [PDF]

European Thyroid Journal
Background: Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability.
Ferdy S van Geest, Wenjun Liao, Paul G Voorhoeve, Willemijn G Leen, Nitash Zwaveling-Soonawala, V Krishna Chatterjee, Sjoerd A A Van den Berg, Frederik A Verburg, Marcel E Meima, Erica L T van den Akker, W Edward Visser   +10 more
doaj   +2 more sources

Update on resistance to thyroid hormone syndromeβ [PDF]

Italian Journal of Pediatrics, 2020
Resistance to thyroid hormone syndrome (RTH) is an autosomal dominant or recessive genetic disease caused by mutation of either the thyroid hormone receptorβ (THR-β) gene or the thyroid hormone receptorα (THR-α) gene.
Hongping Sun, Lin Cao, Rendong Zheng, Shaofeng Xie, Chao Liu   +4 more
doaj   +2 more sources

Resistance to Thyroid Hormone Beta: A Focused Review [PDF]

Frontiers in Endocrinology, 2021
Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid hormone receptor beta (THRB) gene, termed RTHβ.
Theodora Pappa, Samuel Refetoff
doaj   +2 more sources

Resistance to thyroid hormone caused by heterozygous mutation of thyroid hormone receptor B gene c.G1378A: Report of one Chinese pedigree and literature review

Clinical Case Reports, 2021
The same thyroid hormone receptor B gene (THRB) mutation led to thyroid hormone resistance with different clinical manifestations in the kindreds.
Bingkun Huang, Changqin Liu, Fangsen Xiao, Peiying Huang, Jinyang Zeng, Zheng Chen, Mingzhu Lin, Xuejun Li   +7 more
doaj   +1 more source

The Syndromes of Resistance to Thyroid Hormone Beta

罕见病研究, 2023
The syndrome of resistance to thyroid hormone(RTH) is a rare syndrome caused by the mutation of thyroid hormone receptor (TR) gene, which reduces the sensitivity of target organs to thyroid hormone (TH) and leads to the dysfunction of TH. Thyroid hormone
WANG Huangman, SHAN Zhongyan, TENG Xiaochun   +2 more
doaj   +1 more source

Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study

Frontiers in Endocrinology, 2021
ContextThyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones and prediabetes remains unknown.
Bingyang Liu, Zixiao Wang, Jinrong Fu, Haixia Guan, Zhaohui Lyu, Wei Wang   +5 more
doaj   +1 more source

Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

Endocrine Connections, 2022
Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann, Krishna Chatterjee, Carla Moran, Berenike Rogge, Julia Steinhardt, Tobias Wagner-Altendorf, Martin Göttlich, Hannes Schacht, Peter Schramm, Georg Brabant, Thomas F Münte, Anna Cirkel   +11 more
doaj   +1 more source

Resistance to thyroid hormone due to a novel THRB p.Val349Ala mutation in a Taiwanese boy

Journal of the Formosan Medical Association, 2020
Resistance to thyroid hormone (RTH) is a rare congenital disorder characterized by impaired sensitivity of target tissues to thyroid hormone. The disease is mostly caused by heterozygous mutations of thyroid hormone receptor β (THRB) gene.
Zhen Liu, Wen-Yu Tsai, Cheng-Ting Lee
doaj   +1 more source