A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Resistance to thyroid hormone (RTH) is a rare hereditary syndrome with impaired sensitivity to thyroid hormones (TH) and reduced intracellular action of triiodothyronine (T3) caused by genetic variants of TH receptor beta (TRB) or alpha (TRA).
Michela Del Prete +6 more
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Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated
Jae Hee Lee, Eun Young Kim
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Resistance to thyroid hormone beta coexisting with papillary thyroid carcinoma—two case reports of a thyroid hormone receptor beta gene mutation and a literature review [PDF]
Frontiers in Genetics, 2022 Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features, which are caused by mutations in the thyroid hormone receptor beta (THRB) gene ...
Yingxin Fang +6 more
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Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation [PDF]
European Thyroid JournalBackground: Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability.
Ferdy S van Geest +10 more
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Thyroid hormone receptor beta is critical for intestinal remodeling during Xenopus tropicalis metamorphosis [PDF]
Cell & Bioscience, 2020 Background Thyroid hormone (T3) is critical for development in all vertebrates. The mechanism underlying T3 effect has been difficult to study due to the uterus-enclosed nature of mammalian embryos.
Yuki Shibata, Yuta Tanizaki, Yun-Bo Shi
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NeuroImage: Clinical, 2020 Resistance to thyroid hormone beta (RTHβ) is a syndrome of reduced responsiveness of peripheral tissue to thyroid hormone, caused by mutations in the thyroid hormone receptor beta (THRB).
Jan Uter +8 more
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Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study [PDF]
EBioMedicineSummary: Background: Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1 ...
Wenjun Liao +16 more
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Subcellular Distribution of Thyroid Hormone Receptor Beta in Ovarian Cancer. [PDF]
Int J Mol Sci, 2022 Heublein S +10 more
europepmc +2 more sources
Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]
PLoS ONE, 2011 BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen +13 more
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Genome-wide binding patterns of thyroid hormone receptor beta. [PDF]
PLoS ONE, 2014 Thyroid hormone (TH) receptors (TRs) play central roles in metabolism and are major targets for pharmaceutical intervention. Presently, however, there is limited information about genome wide localizations of TR binding sites.
Stephen Ayers +5 more
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