Results 11 to 20 of about 2,553,881 (244)

Thyroid hormone resistance: a novel mutation in thyroid hormone receptor beta (THRB) gene - case report [PDF]

The Turkish Journal of Pediatrics, 2013
Thyroid hormone resistance (THR) is a dominantly inherited syndrome characterized by reduced sensitivity to thyroid hormones. It is usually caused by mutations in the thyroid hormone receptor beta (THRB) gene.
Emregül Işık, Paolo Beck Peccoz, Irene Campi, Alev Özön, Ayfer Alikaşifoğlu, Nazlı Gönç, Nurgün Kandemir   +6 more
doaj   +4 more sources

Resistance to thyroid hormone in a Turkish child with A317T mutation in the thyroid hormone receptor-beta gene [PDF]

The Turkish Journal of Pediatrics, 2008
Resistance to thyroid hormone (RTH) syndrome is a rare disorder usually inherited as an autosomal dominant trait. The combination of elevated serum levels of free thyroid hormones with elevated thyroid-stimulating hormone (TSH) suggest ...
Sükran Poyrazoğlu, Filiz Tütüncüler, Firdevs Baş, Feyza Darendeliler   +3 more
doaj   +2 more sources

A Novel G385E Variant in the Cold Region of the T3-Binding Domain of Thyroid Hormone Receptor Beta Gene and Investigations to Assess Its Clinical Significance. [PDF]

Eur Thyroid J, 2019
Korwutthikulrangsri M, Dosiou C, Dumitrescu AM, Refetoff S.   +3 more
europepmc   +2 more sources

A Mutation in the Thyroid Hormone Receptor Alpha Gene

, 2012
Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2) receptors. Here we describe a child with classic features of hypothyroidism (growth retardation, developmental retardation, skeletal dysplasia, and severe constipation ...
I. S. Farooqi (7604078), D. Halsall (7604075), M. Sarri (7604102), F. Muntoni (7604117), A. Offiah (7604090), E. Schoenmakers (7604060), E. Bochukova (7604051), F. V. Khadem (7604105), J. Reinemund (7604072), E. Henning (7604069), O. Rajanayagam (7604063), K. Chatterjee (7604084), M. Dattani (7604099), K. Downes (7604087), A. Albanese (7604111), N. Schoenmakers (7604054), J. M. Keogh (7604066), John W. R. Schwabe (7604093), E. Gevers (7604096), K. Lindley (7604108), M. Agostini (7604057), M. Gurnell (7604081), M. Bain (7604114), Halsall, David, Maura Agostini, David Halsall, Lindley, Keith, Nadia Schoenmakers, Muntoni, Francesco, Henning, Elana, Sarri, Margarita, Odelia Rajanayagam, Murray Bain, Farooqi, I. Sadaf, Kate Downes, Schoenmakers, Erik; id_orcid, Evelien Gevers, Faraneh Vargha-Khadem, Jana Reinemund, Rajanayagam, Odelia, Offiah, Amaka, Keogh, Julia M., Amaka Offiah, Bochukova, Elena, Margarita Sarri, Keith Lindley, Gurnell, Mark, Francesco Muntoni, Reinemund, Jana, Mehul Dattani, Agostini, Maura, Erik Schoenmakers, Dattani, Mehul, Chatterjee, Krishna, Khadem, Faraneh Vargha, Schoenmakers, Nadia, John W.R. Schwabe, Elana Henning, Schwabe, John W.R., Julia M. Keogh, I. Sadaf Farooqi, Krishna Chatterjee, Assunta Albanese, Downes, Kate, Mark Gurnell, Albanese, Assunta, Gevers, Evelien, Bain, Murray, Elena Bochukova   +68 more
core   +5 more sources

Suppression of thyrotropin secretion during roxadustat treatment for renal anemia in a patient undergoing hemodialysis

BMC Nephrology, 2021
Background Inhibition of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) is a novel choice for the treatment of renal anemia, and an oral HIF-PH inhibitor roxadustat was approved for renal anemia.
Mitsuru Ichii, Katsuhito Mori, Daichi Miyaoka, Mika Sonoda, Yoshihiro Tsujimoto, Shinya Nakatani, Tetsuo Shoji, Masanori Emoto   +7 more
doaj   +1 more source

Contributions of Thyroid Hormone to Cancer Metastasis

Biomedicines, 2018
Acting at a cell surface receptor on the extracellular domain of integrin αvβ3, thyroid hormone analogues regulate downstream the expression of a large panel of genes relevant to cancer cell proliferation, to cancer cell survival pathways, and
Shaker A. Mousa, Gennadi V. Glinsky, Hung-Yun Lin, Osnat Ashur-Fabian, Aleck Hercbergs, Kelly A. Keating, Paul J. Davis   +6 more
doaj   +1 more source

A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity [PDF]

, 2008
Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of
Hiroyuki NAMBA, Namba, Hiroyuki, Saenko, Vladimir, Yamashita, Shunichi, Akulevich, Natallia, Yuka NAKAZAWA, Vladimir SAENKO, Sedliarou, Ilya, Michiko MATSUSE, Rogounovitch, Tatiana, Mitsytake, Norisato, Natallia AKULEVICH, Shunichi YAMASHITA, Tatiana ROGOUNOVITCH, Nakazawa, Yuka, Matsuse, Michiko, Norisato MITSUTAKE, Ilya SEDLIAROU   +17 more
core   +1 more source

Thyroid hormone receptor beta: Relevance in human health and diseases

Endocrine and Metabolic Science, 2023
Thyroid Hormone Receptor (THR) is a member of the nuclear receptor (NR) superfamily, best defined as intracellular ligand-modulated transcription factors. Thyroid hormone (TH), by binding to THR, regulates several physiological and metabolic processes, e.
Ghausiya Rehman, Neha Kumari, Farhad Bano, Rakesh K. Tyagi   +3 more
doaj   +1 more source

Cooperative Subtype Switch of Thyroid Hormone Receptor and Nuclear Receptor Corepressor Related Epithelial–Mesenchymal Transition in Papillary Thyroid Cancer [PDF]

, 2021
Background and Objectives: Although thyroid hormones affect human cancer progression, the regulatory mechanism of thyroid hormone receptors in carcinogenesis has not been elucidated.
이잔디, 김인규, 조영석, 박선미, 이기쁨, Hyunji Kim, Jandee Lee, Seul Gi Lee, Young Suk Jo, In-Kyu Kim, Seonhyang Jeong, Sunmi Park, Gibbeum Lee   +12 more
core   +1 more source

Not all elevated hormones are toxic: A case of thyroid hormone resistance

Journal of Family Medicine and Primary Care, 2016
Resistance to thyroid hormone syndrome (RTH) is a rare disorder and is usually inherited as dominantly negative autosomal trait. RTH is caused by mutations in the thyroid hormone receptor beta.
Rajeev Philip, Mohan Krishnakumar Padikal, Altaf Alinausad, Charamelsankaran Keshavan   +3 more
doaj   +1 more source