Results 31 to 40 of about 2,553,881 (244)

Resistance to thyroid hormone accompanied by atrial fibrillation

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH.
Haruhiro Sato, Yuichiro Tomita
doaj   +1 more source

PM2.5 disrupts thyroid hormone homeostasis through activation of the hypothalamic-pituitary-thyroid (HPT) axis and induction of hepatic transthyretin in female rats 2.5

Ecotoxicology and Environmental Safety, 2021
Fine particulate matter (PM2.5), a ubiquitous environmental pollutant, has been indicated to affect thyroid hormone (TH) homeostasis in women, but the detailed mechanism behind this effect remains unclear.
Xinwen Dong, Weidong Wu, Sanqiao Yao, Haibin Li, Zhichun Li, Li Zhang, Jing Jiang, Jie Xu, Fengquan Zhang   +8 more
doaj   +1 more source

EXPRESSION OF GENES OF IODOTHYRONINE DEIODINASES TYPES 1, 2 AND 3, IODOTYROSINE DEIODINASE, THYROID HORMONE RECEPTOR ALPHA AND BETA AND ACETYLTRANSFERASES TYPES 1 AND 2 IN PATIENTS WITH EUTHYROID AND TOXIC GOITER IN THE IRKUTSK REGION

Байкальский медицинский журнал
Background. Thyroid gland pathology is the leading endocrine disease. According to modern requirements of a personalized approach to medicine, there is a need to study the expression of genes involved in immunoregulation and biosynthesis of thyroid ...
Elena A. Ilyicheva, Lyubov V. Rodionova, Liliya G. Samoilova, Tatiana A. Roy, Gleb A. Bersenev   +4 more
doaj   +1 more source

Resistance to thyroid hormone due to a novel THRB p.Val349Ala mutation in a Taiwanese boy

Journal of the Formosan Medical Association, 2020
Resistance to thyroid hormone (RTH) is a rare congenital disorder characterized by impaired sensitivity of target tissues to thyroid hormone. The disease is mostly caused by heterozygous mutations of thyroid hormone receptor β (THRB) gene.
Zhen Liu, Wen-Yu Tsai, Cheng-Ting Lee
doaj   +1 more source

Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone

, 2006
Context: Heterozygous mutations in thyroid hormone receptor-beta (TR beta) gene are the cause of resistance to thyroid hormone (RTH) in more than 85% of families having the syndrome. In 23% of the families, TR beta gene mutations occur de novo.
Liao, Xiao-Hui, Mamanasiri, Sunee, Demir, TEVFİK, Yesil, Sena, Dumitrescu, Alexandra M., Weiss, Roy E, Weiss, Roy E., Dumitrescu, Alexandra M, Refetoff, Samuel   +8 more
core   +1 more source

Identification of a novel THRB mutation causing thyroid hormone resistance syndrome [PDF]

Archives of Endocrinology and Metabolism
Resistance to thyroid hormone syndrome (RTHS) is a rare disorder caused by mutations in the thyroid hormone receptor beta (THRB) gene, resulting in impaired action of thyroid hormones on target tissues and organs.
Jing Yang, Chuan Wang, Li Quan, Sheng Jiang   +3 more
doaj   +2 more sources

Resistance to Thyroid Hormone Beta: A Focused Review

Frontiers in Endocrinology, 2021
Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid hormone receptor beta (THRB) gene, termed RTHβ.
Theodora Pappa, Samuel Refetoff
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice

, 1997
Thyroid hormone responsive genes can be both positively and negatively regulated by thyroid hormone. TSH is down-regulated by thyroid hormone and rises during thyroid hormone deprivation.
Pohlenz, J, Forrest, D, Weiss, R E, Cua, K, Curran, T, Refetoff, S   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source