Results 31 to 40 of about 2,507,137 (250)

Molecular dynamics approach to the I431V mutational impact on thyroid hormone receptor-beta

Bibechana, 2018
The point mutations like I431V on thyroid hormone receptor-beta (THR-β) gene cause resistance to thyroid hormones (RTH) with the clinical diagnosis of elevated free triiodothyronine (T3) and free thyroxin (T4) but not suppressed thyroid stimulating ...
Tika Ram Lamichhane, Sharma Paudel, Binod Kumar Yadav, Hari Prasad Lamichhane   +3 more
doaj   +3 more sources

T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation

Molecular Metabolism, 2022
Objectives: Thyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. In the present study, we asked whether T3 and glucose signaling pathways coordinately regulate transcription of genes important ...
Liora S. Katz, Carmen Argmann, Luca Lambertini, Donald K. Scott   +3 more
doaj   +1 more source

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

Frontiers in Pharmacology, 2022
Objective: There is little literature about whether antihypertensive drugs would affect thyroid function in patients with euthyroid type 2 diabetes, which was significant in maintaining a proper balance of thyroid function.
Lijuan Yang, Xiuqin Sun, Yi Zhao, Hong Tao   +3 more
doaj   +1 more source

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

, 2008
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay.
Soni, Krunal, Raval, Preeti, Joharapurkar, A., Bandyopadhyay, Debdutta, Yevale, Digambar, Raval, S., Soni, K., Gandhi, Neha, Raval, P., Jain, Mukul R., Modi, H., Modi, Honey, Yevale, D., Bandyopadhyay, D., Jain, M., Jogiya, Digvijay, Raval, Saurin, Joharapurkar, Amit, Patel, P., Jogiya, D., Patel, Pankaj R.   +20 more
core   +1 more source

A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity [PDF]

, 2008
Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of
Hiroyuki NAMBA, Namba, Hiroyuki, Saenko, Vladimir, Yamashita, Shunichi, Akulevich, Natallia, Yuka NAKAZAWA, Vladimir SAENKO, Sedliarou, Ilya, Michiko MATSUSE, Rogounovitch, Tatiana, Mitsytake, Norisato, Natallia AKULEVICH, Shunichi YAMASHITA, Tatiana ROGOUNOVITCH, Nakazawa, Yuka, Matsuse, Michiko, Norisato MITSUTAKE, Ilya SEDLIAROU   +17 more
core   +1 more source

Methods to assess iron and iodine status [PDF]

, 2008
Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, Michael B., Zimmermann, M.B.
core   +1 more source

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Cell Reports, 2019
Summary: Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially ...
Kornelia Johann, Anna Lena Cremer, Alexander W. Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W. Dalley, Heiko Backes, Jens Mittag   +20 more
doaj   +1 more source

Characterization of a Low Affinity Thyroid Hormone Receptor Binding Site within the Rat GLUT4 Gene Promoter

, 2023
Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle.
Dohm, G. Lynis, Torrance, Christopher J., Usala, Stephen J., NC DOCKS at East Carolina University, Pessin, Jeffrey E.   +4 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Update on resistance to thyroid hormone syndromeβ

Italian Journal of Pediatrics, 2020
Resistance to thyroid hormone syndrome (RTH) is an autosomal dominant or recessive genetic disease caused by mutation of either the thyroid hormone receptorβ (THR-β) gene or the thyroid hormone receptorα (THR-α) gene.
Hongping Sun, Lin Cao, Rendong Zheng, Shaofeng Xie, Chao Liu   +4 more
doaj   +1 more source