Results 31 to 40 of about 948 (200)

T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation

Molecular Metabolism, 2022
Objectives: Thyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. In the present study, we asked whether T3 and glucose signaling pathways coordinately regulate transcription of genes important ...
Liora S. Katz, Carmen Argmann, Luca Lambertini, Donald K. Scott   +3 more
doaj   +1 more source

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

, 2008
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay.
Soni, Krunal, Raval, Preeti, Joharapurkar, A., Bandyopadhyay, Debdutta, Yevale, Digambar, Raval, S., Soni, K., Gandhi, Neha, Raval, P., Jain, Mukul R., Modi, H., Modi, Honey, Yevale, D., Bandyopadhyay, D., Jain, M., Jogiya, Digvijay, Raval, Saurin, Joharapurkar, Amit, Patel, P., Jogiya, D., Patel, Pankaj R.   +20 more
core   +1 more source

The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]

, 2009
Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Ladds, Graham, Hill, Claire, Goddard, Alan, Davey, John   +3 more
core   +1 more source

Effects of Antihypertensive Drugs on Thyroid Function in Type 2 Diabetes Patients With Euthyroidism

Frontiers in Pharmacology, 2022
Objective: There is little literature about whether antihypertensive drugs would affect thyroid function in patients with euthyroid type 2 diabetes, which was significant in maintaining a proper balance of thyroid function.
Lijuan Yang, Xiuqin Sun, Yi Zhao, Hong Tao   +3 more
doaj   +1 more source

Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes

, 2000
Most people with resistance to thyroid hormone have mutant thyroid hormone receptors that interfere with the function of the normal receptor and produce a dominant mode of inheritance.
Refetoff, Samuel, Sadow, Peter, Reutrakul, Sirimon, Weiss, Roy   +3 more
core   +1 more source

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Cell Reports, 2019
Summary: Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially ...
Kornelia Johann, Anna Lena Cremer, Alexander W. Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W. Dalley, Heiko Backes, Jens Mittag   +20 more
doaj   +1 more source

Receptors | Thyroid-Stimulating Hormone/Luteinizing Hormone/Follicle-Stimulating Hormone Receptors

, 2021
International audienceThe thyroid-stimulating hormone receptor (TSHR), luteinizing hormone receptor (LHCGR), and follicle-stimulating hormone receptor (FSHR) are collectively referred to as the glycoprotein hormone receptors because they bind ...
Crépieux, Pascale, Combarnous, Yves, Eric Reiter, Yves Combarnous, Pascal Crépieux, Reiter, Eric   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Exploring the influence mechanism of dissolved organic matter on the bioavailability and thyroid hormone disrupting effect of zinc: A case study of effluents from galvanizing plants

Ecotoxicology and Environmental Safety, 2022
The effect of dissolved organic matter (DOM) on metal bioavailability and toxicity is a complex process. Effluents from galvanizing plants containing large amounts of DOM and Zn were selected to investigate the potential influence and mechanism of DOM on
Jian Li, Ying Xu, Kun Yin, Rongfang Wang, Xueru Guo, Jinsheng Wang, Lei Zheng   +6 more
doaj   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2017
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core